Sandbox Reserved 429: Difference between revisions
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Normally, the bacteria produce the penicillin binding proteins with low penicillin-affinity<scene name='48/483886/Conserved_residues_of_pbp/2'>low affinity</scene> by transformation, which is a kind of gene modification. Through this way, bacteria could have a relatively higher resistance to β-lactams antibiotics. But staphylococcus is a special case, it strengthens the drug resistance by two ways instead of gene exchange. By the raised dissociation constants for the non-covalent pre-acylation and the dropped penicillin-sensitive microscopic rate constant for acylation, staphylococcus enhance its own drug resistance.<ref>PMID:15226303</ref> | Normally, the bacteria produce the penicillin binding proteins with low penicillin-affinity<scene name='48/483886/Conserved_residues_of_pbp/2'>low affinity</scene> by transformation, which is a kind of gene modification. Through this way, bacteria could have a relatively higher resistance to β-lactams antibiotics. But staphylococcus is a special case, it strengthens the drug resistance by two ways instead of gene exchange. By the raised dissociation constants for the non-covalent pre-acylation and the dropped penicillin-sensitive microscopic rate constant for acylation, staphylococcus enhance its own drug resistance.<ref>PMID:15226303</ref> | ||
And the solution to the penicillin binding proteins drug resistance could be semi-synthetic β-lactams. The mechanism is that semi-synthetic β-lactams have the alternative side chain compared to the normal penicillins and it will make penicillin binding proteins have the higher affinity to it and as a result the increasing drug resistance will be solved. | And the solution to the penicillin binding proteins drug resistance could be semi-synthetic β-lactams. The mechanism is that semi-synthetic β-lactams have the alternative side chain compared to the normal penicillins and it will make penicillin binding proteins have the higher affinity to it and as a result the increasing drug resistance will be solved.<ref>PMID:3082839</ref> | ||
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==References== | ==References== | ||
<references/> | <references/> | ||
