Sandbox Reserved 425: Difference between revisions

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==Quiz Question 1==

Ponatinib is unique in it's ability to bind to the mutated BCR-~~ALB~~ because of it's preference to shift to the DFG-out conformation. In theory, if a competitive inhibitor was created by nature to prevent Ponatinib from binding to BCR-~~ALB~~ to further its drug resistance, what specific structure characteristics would the inhibitor need to posses? Consider the unique binding methods of Ponatinib and the <scene name='48/483882/Active_sitezoom/1'>DFG-out</scene> conformation.

Ponatinib is unique in it's ability to bind to the mutated BCR-ABL because of it's preference to shift to the DFG-out conformation. In theory, if a competitive inhibitor was created by nature to prevent Ponatinib from binding to BCR-ABL to further its drug resistance, what specific structure characteristics would the inhibitor need to posses? Consider the unique binding methods of Ponatinib and the <scene name='48/483882/Active_sitezoom/1'>DFG-out</scene> conformation.

a. ~~A small~~, fully conjugated aromatic system with no electronegative substituents, to prevent unwanted hydrogen bonding.

a. Small, fully conjugated aromatic system with no electronegative substituents, to prevent unwanted hydrogen bonding.

b. ~~Benzoic acid bonded to another aromatic~~ ring ~~with at least~~ one ~~substituent that creates~~ a ~~large dipole moment;~~ such as a halogen.

b. Multiple ring system, one ring, particularly for hydrogen bonding and another capable of binding in a hydrophobic pocket such as halogen substituents.

c. ~~A polymer~~ chain with an ester linkage and a hydroxyl end group .

c. Polymer chain with an ester linkage and a hydroxyl end group .

d. ~~A metal~~ center that binds four large, nonpolar hydrocarbon ligands that exhibit significant steric hindrance.

d. Metal center that binds four large, nonpolar hydrocarbon ligands that exhibit significant steric hindrance.

==See Also==

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 ==Quiz Question 1==
-Ponatinib is unique in it's ability to bind to the mutated BCR-ALB because of it's preference to shift to the DFG-out conformation. In theory, if a competitive inhibitor was created by nature to prevent Ponatinib from binding to BCR-ALB to further its drug resistance, what specific structure characteristics would the inhibitor need to posses? Consider the unique binding methods of Ponatinib and the <scene name='48/483882/Active_sitezoom/1'>DFG-out</scene>  conformation.
+Ponatinib is unique in it's ability to bind to the mutated BCR-ABL because of it's preference to shift to the DFG-out conformation. In theory, if a competitive inhibitor was created by nature to prevent Ponatinib from binding to BCR-ABL to further its drug resistance, what specific structure characteristics would the inhibitor need to posses? Consider the unique binding methods of Ponatinib and the <scene name='48/483882/Active_sitezoom/1'>DFG-out</scene>  conformation.
-a. A small, fully conjugated aromatic system with no electronegative substituents, to prevent unwanted hydrogen bonding.
+a. Small, fully conjugated aromatic system with no electronegative substituents, to prevent unwanted hydrogen bonding.
-b. Benzoic acid bonded to another aromatic ring with at least one substituent that creates a large dipole moment; such as a halogen.
+b. Multiple ring system, one ring, particularly for hydrogen bonding and another capable of binding in a hydrophobic pocket such as halogen substituents.
-c. A polymer chain with an ester linkage and a hydroxyl end group .
+c. Polymer chain with an ester linkage and a hydroxyl end group .
-d. A metal center that binds four large, nonpolar hydrocarbon ligands that exhibit significant steric hindrance.
+d. Metal center that binds four large, nonpolar hydrocarbon ligands that exhibit significant steric hindrance.
 ==See Also==