Sandbox Reserved 427: Difference between revisions

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'''The Vitamin D Binding Site'''

The Vitamin D binding site is located in domain I and contains helices 1 through 6. The binding site is lined with hydrophobic residues that interact with the hydrophobic parts of the vitamin D3 ligand.<scene name='48/483884/Site_where_25ohd3_binds/2'>Hydrogen Bonds</scene> are formed between, the 25-hydroxyl and Tyr 32 with a distance of 2.85 angstroms, the 3-hydroxyl and Ser 76 with a distance of 3.01 angstroms and Met 109 with a distance of 3.01 angstroms. Different analogs of the vitamin D3 ligand influence hydrogen bond locations and binding affinities. <scene name='48/483884/Jy_site_where_25ohd3_binds/4'>The JY analog</scene>, for example, has a binding affinity to DBP of 1314, which is much greater compared to the affinity of 25OHD3, which is 667. This is due to the <scene name='48/483884/Stacking_stabilization_with_jy/2'>stacking of the aromatic sidechain of JY</scene> and the aromatic residues of Phe 24, Tyr 34, Phe 36, and Tyr 38.

The Vitamin D binding site is located in domain I and contains helices 1 through 6. The binding site is lined with hydrophobic residues that interact with the hydrophobic parts of the vitamin D3 ligand.<scene name='48/483884/Site_where_25ohd3_binds/2'>Hydrogen Bonds</scene> are formed between, the 25-hydroxyl and Tyr 32 with a distance of 2.85 angstroms, the 3-hydroxyl and Ser 76 with a distance of 3.01 angstroms and Met 109 with a distance of 3.01 angstroms. Different analogs of the vitamin D3 ligand influence hydrogen bond locations and binding affinities. <scene name='48/483884/Jy_site_where_25ohd3_binds/4'>The JY analog</scene>, for example, has a binding affinity to DBP of 1314, which is much greater compared to the affinity of 25OHD3, which is 667. This is due to the <scene name='48/483884/Stacking_stabilization_with_jy/3'>stacking of the aromatic sidechain of JY</scene> and the aromatic residues of Phe 24, Tyr 34, Phe 36, and Tyr 38.

'''Biological Relevance of The Vitamin D Binding Site'''

Sandbox Reserved 427: Difference between revisions

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@@ Line 35: / Line 35: @@
 '''The Vitamin D Binding Site'''
-The Vitamin D binding site is located in domain I and contains helices 1 through 6. The binding site is lined with hydrophobic residues that interact with the hydrophobic parts of the vitamin D3 ligand.<scene name='48/483884/Site_where_25ohd3_binds/2'>Hydrogen Bonds</scene> are formed between, the 25-hydroxyl and Tyr 32 with a distance of 2.85 angstroms, the 3-hydroxyl and Ser 76 with a distance of 3.01 angstroms and Met 109 with a distance of 3.01 angstroms. Different analogs of the vitamin D3 ligand influence hydrogen bond locations and binding affinities. <scene name='48/483884/Jy_site_where_25ohd3_binds/4'>The JY analog</scene>, for example, has a binding affinity to DBP of 1314, which is much greater compared to the affinity of 25OHD3, which is 667. This is due to the <scene name='48/483884/Stacking_stabilization_with_jy/2'>stacking of the aromatic sidechain of JY</scene> and the aromatic residues of Phe 24, Tyr 34, Phe 36, and Tyr 38.
+The Vitamin D binding site is located in domain I and contains helices 1 through 6. The binding site is lined with hydrophobic residues that interact with the hydrophobic parts of the vitamin D3 ligand.<scene name='48/483884/Site_where_25ohd3_binds/2'>Hydrogen Bonds</scene> are formed between, the 25-hydroxyl and Tyr 32 with a distance of 2.85 angstroms, the 3-hydroxyl and Ser 76 with a distance of 3.01 angstroms and Met 109 with a distance of 3.01 angstroms. Different analogs of the vitamin D3 ligand influence hydrogen bond locations and binding affinities. <scene name='48/483884/Jy_site_where_25ohd3_binds/4'>The JY analog</scene>, for example, has a binding affinity to DBP of 1314, which is much greater compared to the affinity of 25OHD3, which is 667. This is due to the <scene name='48/483884/Stacking_stabilization_with_jy/3'>stacking of the aromatic sidechain of JY</scene> and the aromatic residues of Phe 24, Tyr 34, Phe 36, and Tyr 38.
 '''Biological Relevance of The Vitamin D Binding Site'''