Sandbox Reserved 429: Difference between revisions

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==Quiz Question 1==
==Quiz Question 1==


Question related to PBP evolution and developing resistance to ß-lactams, likely related to active site mutations.
The binding pocket for PTLV (all residues within 5Å of the molecule) is shown <scene name='48/483886/Pltv_binding_pocket/1'>here</scene> colored from most conserved to most variable.
Shows the <scene name='48/483886/Conserved_residues_of_pbp/2'>conserved residues of Penicillin Binding Protein</scene> from most conserved to most variable.{{Template:ColorKey_ConSurf}}
 
{{Template:ColorKey_ConSurf}}
 
Would it be evolutionarily advantageous to mutate this binding pocket to prevent inhibition by PTLV? Explain.
 
Propose a method by which bacteria might develop resistance to PLTV.




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