Sandbox Reserved 427: Difference between revisions
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==Additional Features== | ==Additional Features== | ||
=====Actin Binding Interactions===== | =====Actin Binding Interactions===== | ||
The most well documented auxiliary function of Vitamin D binding protein is its ability to bind and sequester circulating actin monomers. [4] The actin interaction occur at the sites shown in <scene name= | The most well documented auxiliary function of Vitamin D binding protein is its ability to bind and sequester circulating actin monomers. [4] The actin interaction occur at the sites shown in <scene name='48/483884/Dbp_actin_binding_site/2'>red</scene>. While the vitamin D binding domain resides between leucine 35 and serine 49, the actin binding domain lies far away in sequence, between glycine 373 and glycine 403, the site is <scene name='48/483884/Dbp_actin_dbinding_distance/1'>much closer</scene> in the folded protein, with residues serine 42 and lysine 388 only 21.44Å apart on complementary subunits or 43.58Å apart on the same subunit. | ||
At the level of the organism, this actin binding of DBP is an important mechanism for clearing actin from necrotic or apoptotic tissue [1]. This actin binding quality serves to prevent clotting and actin toxicity, as large quantities of circulating actin have been shown to be fatal to mice. | At the level of the organism, this actin binding of DBP is an important mechanism for clearing actin from necrotic or apoptotic tissue [1]. This actin binding quality serves to prevent clotting and actin toxicity, as large quantities of circulating actin have been shown to be fatal to mice. | ||
