Sandbox Reserved 1174: Difference between revisions

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 === Structural Stabilization ===
-There are many different stabilizing factors in the structure of this receptor. There are three native <scene name='72/721545/Disulfides/2'>disulfide bonds</scene> in the extracellular region.<ref name= "Chrencik"/> One of these bonds constrains the N terminal helix to extracellular loop 2. The <scene name='72/721545/N-terminus/2'>N-terminus</scene> functions like a cap on the extracellular side of the protein, packing tightly against ECL1 and ECL2. It also provides <scene name='72/721545/34_39_40/3'>polar amino acids</scene> that interact with the ligand when bound.
+Three native <scene name='72/721545/Disulfides/2'>disulfide bonds</scene> in the extracellular region of this receptor provide fold stability.<ref name= "Chrencik"/> The first disulfide bond constrains the N terminal helix to extracellular loop(ECL) 2. The second disulfide bond shapes ECL2, and the third binds ECL3 to one of the transmembrane alpha helices. The <scene name='72/721545/N-terminus/2'>N-terminus</scene> functions like a cap on the extracellular side of the protein, packing tightly against ECL1 and ECL2. The N-terminus alpha helix also provides <scene name='72/721545/34_39_40/3'>polar amino acids</scene> that interact with the ligand when bound.
 === Binding Pocket ===

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