Sandbox Reserved 1174: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 9: | Line 9: | ||
Extracellularly, LPA is produced from lysophosphatidylcholine by the enzyme autotaxin.<ref name= "Chrencik"/> Autotaxin was originally linked with metastasis, and this link was later discovered to be mediated through the production of LPA, which signals cell proliferation.<ref name= "Boutin"> DOI: 10.1007/s00018-009-0056-9 </ref> All of LPA’s activities are receptor mediated; the signalling lipid interacts with at least six G-protein coupled receptors LPA<sub>1</sub>-LPA<sub>6</sub>. | Extracellularly, LPA is produced from lysophosphatidylcholine by the enzyme autotaxin.<ref name= "Chrencik"/> Autotaxin was originally linked with metastasis, and this link was later discovered to be mediated through the production of LPA, which signals cell proliferation.<ref name= "Boutin"> DOI: 10.1007/s00018-009-0056-9 </ref> All of LPA’s activities are receptor mediated; the signalling lipid interacts with at least six G-protein coupled receptors LPA<sub>1</sub>-LPA<sub>6</sub>. | ||
