Nos1: Difference between revisions

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== Location ==

The human gene NOS1, found on chromosome 12, encodes for a nitric oxide synthase. Nitric oxide synthases consume L-arginine to produce nitric oxide. The chemical equation is shown below.

The human gene NOS1, found on chromosome 12, encodes for a nitric oxide synthase which is ubiquitously expressed. Nitric oxide synthases consume L-arginine to produce nitric oxide. The chemical equation is shown below.

2 L-arginine + 3 NADPH + 4 O(2) = 2 L- citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O

Nitric oxide is used in a wide variety of processes. A few examples of molecular processes include heme binding, NADP binding, calcium signaling, and oxidation-reduction reactions. Biological examples include regulation of cardiac muscle contraction, blood coagulation, aging, and regulation of neurogenesis. There are three known isoforms known for NOS1 in humans produced by alternative splicing. ~~These~~ isoforms are reffered to as neuronal NOS (nNOS), endothelial NOS (eNOS), and cytokine-inducible NOS (iNOS).

Nitric oxide is used in a wide variety of processes. A few examples of molecular processes include heme binding, NADP binding, calcium signaling, and oxidation-reduction reactions. Biological examples include regulation of cardiac muscle contraction, blood coagulation, aging, and regulation of neurogenesis. There are three known isoforms known for NOS1 in humans produced by alternative splicing, as well as four transcript variants for NOS1. The alternatively-spliced isoforms are reffered to as neuronal NOS (nNOS or NOS1), endothelial NOS (eNOS or NOS3), and cytokine-inducible NOS (iNOS or NOS2). Moderate expression of NOS1 has been observed in skeletal muscle, brain, testicular, lung, and kidney tissue. Low expression has been observed in heart, adrenal gland, and retinal tissues.

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@@ Line 5: / Line 5: @@
 == Location ==
-The human gene NOS1, found on chromosome 12, encodes for a nitric oxide synthase. Nitric oxide synthases consume L-arginine to produce nitric oxide. The chemical equation is shown below.
+The human gene NOS1, found on chromosome 12, encodes for a nitric oxide synthase which is ubiquitously expressed. Nitric oxide synthases consume L-arginine to produce nitric oxide. The chemical equation is shown below.
 L-arginine + 3 NADPH + 4 O(2) = 2 L- citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O
-Nitric oxide is used in a wide variety of processes. A few examples of molecular processes include heme binding, NADP binding, calcium signaling, and oxidation-reduction reactions. Biological examples include regulation of cardiac muscle contraction, blood coagulation, aging, and regulation of neurogenesis. There are three known isoforms known for NOS1 in humans produced by alternative splicing. These isoforms are reffered to as neuronal NOS (nNOS), endothelial NOS (eNOS), and cytokine-inducible NOS (iNOS).
+Nitric oxide is used in a wide variety of processes. A few examples of molecular processes include heme binding, NADP binding, calcium signaling, and oxidation-reduction reactions. Biological examples include regulation of cardiac muscle contraction, blood coagulation, aging, and regulation of neurogenesis. There are three known isoforms known for NOS1 in humans produced by alternative splicing, as well as four transcript variants for NOS1. The alternatively-spliced isoforms are reffered to as neuronal NOS (nNOS or NOS1), endothelial NOS (eNOS or NOS3), and cytokine-inducible NOS (iNOS or NOS2).  Moderate expression of NOS1 has been observed in skeletal muscle, brain, testicular, lung, and kidney tissue. Low expression has been observed in heart, adrenal gland, and retinal tissues.