Major histocompatibility complex: Difference between revisions
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<StructureSection load='3ox8' size='350' side='right' caption='Human MHC class I | <StructureSection load='3ox8' size='350' side='right' caption='Human MHC class I antigen (grey, yellow) with β 2-microglobulin (green, magenta) and peptide from pre-core-protein (pink, cyan) [[3ox8]]' scene=''> | ||
== Function == | == Function == | ||
''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ||
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*[[MR1 Binds Vitamin Metabolites]].<br /> | *[[MR1 Binds Vitamin Metabolites]].<br /> | ||
* '''MHC class II''' are found in professional antigen-presenting cells like macrophages. These cell surface proteins display peptides from cellular extrinsic proteins<ref>PMID:15120183</ref>. | * '''MHC class II''' are found in professional antigen-presenting cells like macrophages. These cell surface proteins display peptides from cellular extrinsic proteins<ref>PMID:15120183</ref>. | ||
== Structural highlights == | |||
The peptide derived from Hepatitis virus binds MHC in a peptide-recognition groove and makes various interactions with side chains and with water molecules<ref>PMID:21538979</ref>. | |||
</StructureSection> | </StructureSection> | ||
