Sandbox Reserved 1172: Difference between revisions

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== Introduction ==

Lysophosphatidic Acid Receptor 1 (commonly referred to as LPA1) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA1-LPA6). These receptors bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent [https://en.wikipedia.org/wiki/Mitogen mitogen] upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref> LPA1 is part of the larger [http://jb.oxfordjournals.org/content/131/6/767 EDG receptor family], which includes the more widely studied sphingosine 1-phopshate receptors.<ref name="regpeps">PMID: 26091040</ref> This receptor is responsible for initiating signaling cascades that result in growth, survival, and movement of cells, as well as neural cell development.

Lysophosphatidic Acid Receptor 1 (commonly referred to as LPA1) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA1-LPA6). These receptors bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent [https://en.wikipedia.org/wiki/Mitogen mitogen] upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref> LPA1 is part of the larger [http://jb.oxfordjournals.org/content/131/6/767 EDG receptor family], which includes the more widely studied sphingosine 1-phopshate receptors.<ref name="regpeps">PMID: 26091040</ref> This receptor is responsible for initiating signaling cascades that result in growth, survival, and movement of cells, as well as neural cell development.<ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.' </ref><ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref>

== Structure ==

[[Image:Pic2proteo3.png|275 px|left|thumb|Figure 1: Surface representation of the LPA1 receptor in tan interacting with its antagonist, ON7, shown in green and red sticks.The exterior of the protein was partially cut away to display the interior binding pocket.]]

Sandbox Reserved 1172: Difference between revisions

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 == Introduction ==
-Lysophosphatidic Acid Receptor 1 (commonly referred to as LPA<sub>1</sub>) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA<sub>1</sub>-LPA<sub>6</sub>). These receptors bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent [https://en.wikipedia.org/wiki/Mitogen mitogen] upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref> LPA<sub>1</sub> is part of the larger [http://jb.oxfordjournals.org/content/131/6/767 EDG receptor family], which includes the more widely studied sphingosine 1-phopshate receptors.<ref name="regpeps">PMID: 26091040</ref> This  receptor is responsible for initiating signaling cascades that result in growth, survival, and movement of cells, as well as neural cell development.
+Lysophosphatidic Acid Receptor 1 (commonly referred to as LPA<sub>1</sub>) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA<sub>1</sub>-LPA<sub>6</sub>). These receptors bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent [https://en.wikipedia.org/wiki/Mitogen mitogen] upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref> LPA<sub>1</sub> is part of the larger [http://jb.oxfordjournals.org/content/131/6/767 EDG receptor family], which includes the more widely studied sphingosine 1-phopshate receptors.<ref name="regpeps">PMID: 26091040</ref> This  receptor is responsible for initiating signaling cascades that result in growth, survival, and movement of cells, as well as neural cell development.<ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.' </ref><ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref>
 == Structure ==
 [[Image:Pic2proteo3.png|275 px|left|thumb|Figure 1: Surface representation of the LPA<sub>1</sub> receptor in tan interacting with its antagonist, ON7, shown in green and red sticks.The exterior of the protein was partially cut away to display the interior binding pocket.]]