Sandbox WWC3: Difference between revisions

Line 11:

===Selectivity Filter===

This channel conducts sodium at nearly the rate of free diffusion <ref name= "crystal"/>. This pore consists of an outer funnel-like vestibule, a selectivity filter, a central cavity, and an intracellular activation gate <ref name= "crystal"/>. Unlike the K+ channel, the Na+ channel conducts sodium ions that are hydrated with four water molecules <ref name= "crystal"/>. Much like with the gating mechanism, each domain does not contribute equally to the selectivity of the pore <ref name= "struct"/>, but the channel selects for sodium 100x greater than it selects for any other ion <ref name= "struct"/>.

It is likely that the sodium ion can get much closer to the channel than a larger K+ ion. When the ion reaches this distance, there is a more efficient removal of water and the sodium interacts with the Glu117 side chains. Two side chains interact directly with the sodium ion and two side chains form hydrogen bonds with the water molecules <ref name= "crystal"/>. The pore is made up of THR 175, LEU 176, GLU 177 and SER 178 <ref name= "crystal"/>. The GLU side chains act as hydrogen bond acceptors two in-plane molecules surrounding the sodium ion. The other two water molecules would be axial to the sodium ion. Full rehydration would occur when the ion moves next to the LEU and THR residues. Full rehydration then allows the sodium ion to enter the cytoplasm.

It is likely that the sodium ion can get much closer to the channel than a larger K+ ion. When the ion reaches this distance, there is a more efficient removal of water and the sodium interacts with the Glu117 side chains. Two side chains interact directly with the sodium ion and two side chains form hydrogen bonds with the water molecules <ref name= "crystal"/>. The pore is made up of THR 175, LEU 176, GLU 177 and SER 178 <ref name= "crystal"/>. The GLU side chains act as hydrogen bond acceptors two in-plane molecules surrounding the sodium ion<ref name= "crystal"/>. The other two water molecules would be axial to the sodium ion<ref name= "crystal"/>. Full rehydration would occur when the ion moves next to the LEU and THR residues<ref name= "crystal"/>. Full rehydration then allows the sodium ion to enter the cytoplasm<ref name= "crystal"/>.

To see the selectivity filter, click <scene name='69/696300/Selectivity_pore/2'>here</scene>. THR 175 is blue, LEU 176 is yellow, GLU 177 is red and SER 178 is black.

===Alpha and Beta Subunits===

There are nine different alpha subunits named NaV1.1 through NAV1.9<ref name = "sod"/>. Genes are SCN1 through SCN11<ref name = "sod"/>. You can find the structures and more information below.

[https://en.wikipedia.org/wiki/Nav1.1 NaV1.1]: found in central and peripheral neurons and myocytes. Click <scene name='69/696300/Nav1_1/1'>here</scene> for the structure of the NaV1.1 inactivation gate.

[https://en.wikipedia.org/wiki/Nav1.2 NaV1.2]: found in central and peripheral neurons. Click <scene name='69/696300/Nav1_2/1'>here</scene> for the structure of the NaV1.2 C terminal domain in complex with FGF13U and Ca2+/calmodulin.

[https://en.wikipedia.org/wiki/SCN3A NaV1.3]: found in central and peripheral neurons and cardiac myocytes.

[https://en.wikipedia.org/wiki/Nav1.4 NaV1.4]: found in skeletal muscle.

[https://en.wikipedia.org/wiki/Nav1.5 NaV1.5]: found in cardiac myocytes, uninnervated skeletal muscle, central neurons, gastrointestinal smooth muscle cells, and interstitial cells of Cajal. Click <scene name='69/696300/Nav1_5/1'>here</scene> for the structure of the NaV1.5 C terminal domain in complex with FGF12B and Ca2+/calmodulin.

[https://en.wikipedia.org/wiki/SCN8A NaV1.6]: found in central neurons, dorsal root ganglia, peripheral neurons, heart and glial cells.

[https://en.wikipedia.org/wiki/Nav1.7 NaV1.7]: found in dorsal root ganglia, sympathetic neurons, Schwann cells and neuroendocrine cells.

[https://en.wikipedia.org/wiki/Nav1.8 NaV1.8]: found in dorsal root ganglia.

[https://en.wikipedia.org/wiki/Nav1.9 NaV1.9]: found in dorsal root ganglia.

Sandbox WWC3: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 11: / Line 11: @@
 ===Selectivity Filter===
 This channel conducts sodium at nearly the rate of free diffusion <ref name= "crystal"/>. This pore consists of an outer funnel-like vestibule, a selectivity filter, a central cavity, and an intracellular activation gate <ref name= "crystal"/>. Unlike the K+ channel, the Na+ channel conducts sodium ions that are hydrated with four water molecules <ref name= "crystal"/>. Much like with the gating mechanism, each domain does not contribute equally to the selectivity of the pore <ref name= "struct"/>, but the channel selects for sodium 100x greater than it selects for any other ion <ref name= "struct"/>.
-It is likely that the sodium ion can get much closer to the channel than a larger K+ ion. When the ion reaches this distance, there is a more efficient removal of water and the sodium interacts with the Glu117 side chains. Two side chains interact directly with the sodium ion and two side chains form hydrogen bonds with the water molecules <ref name= "crystal"/>. The pore is made up of THR 175, LEU 176, GLU 177 and SER 178 <ref name= "crystal"/>. The GLU side chains act as hydrogen bond acceptors two in-plane molecules surrounding the sodium ion. The other two water molecules would be axial to the sodium ion. Full rehydration would occur when the ion moves next to the LEU and THR residues. Full rehydration then allows the sodium ion to enter the cytoplasm.
+It is likely that the sodium ion can get much closer to the channel than a larger K+ ion. When the ion reaches this distance, there is a more efficient removal of water and the sodium interacts with the Glu117 side chains. Two side chains interact directly with the sodium ion and two side chains form hydrogen bonds with the water molecules <ref name= "crystal"/>. The pore is made up of THR 175, LEU 176, GLU 177 and SER 178 <ref name= "crystal"/>. The GLU side chains act as hydrogen bond acceptors two in-plane molecules surrounding the sodium ion<ref name= "crystal"/>. The other two water molecules would be axial to the sodium ion<ref name= "crystal"/>. Full rehydration would occur when the ion moves next to the LEU and THR residues<ref name= "crystal"/>. Full rehydration then allows the sodium ion to enter the cytoplasm<ref name= "crystal"/>.
 To see the selectivity filter, click <scene name='69/696300/Selectivity_pore/2'>here</scene>. THR 175 is blue, LEU 176 is yellow, GLU 177 is red and SER 178 is black.
+===Alpha and Beta Subunits===
+There are nine different alpha subunits named NaV1.1 through NAV1.9<ref name = "sod"/>. Genes are SCN1 through SCN11<ref name = "sod"/>. You can find the structures and more information below.
+[https://en.wikipedia.org/wiki/Nav1.1 NaV1.1]: found in central and peripheral neurons and myocytes. Click <scene name='69/696300/Nav1_1/1'>here</scene> for the structure of the NaV1.1 inactivation gate.
+[https://en.wikipedia.org/wiki/Nav1.2 NaV1.2]: found in central and peripheral neurons. Click <scene name='69/696300/Nav1_2/1'>here</scene> for the structure of the NaV1.2 C terminal domain in complex with FGF13U and Ca2+/calmodulin.
+[https://en.wikipedia.org/wiki/SCN3A NaV1.3]: found in central and peripheral neurons and cardiac myocytes.
+[https://en.wikipedia.org/wiki/Nav1.4 NaV1.4]: found in skeletal muscle.
+[https://en.wikipedia.org/wiki/Nav1.5 NaV1.5]: found in cardiac myocytes, uninnervated skeletal muscle, central neurons, gastrointestinal smooth muscle cells, and interstitial cells of Cajal. Click <scene name='69/696300/Nav1_5/1'>here</scene> for the structure of the NaV1.5 C terminal domain in complex with FGF12B and Ca2+/calmodulin.
+[https://en.wikipedia.org/wiki/SCN8A NaV1.6]: found in central neurons, dorsal root ganglia, peripheral neurons, heart and glial cells.
+[https://en.wikipedia.org/wiki/Nav1.7 NaV1.7]: found in dorsal root ganglia, sympathetic neurons, Schwann cells and neuroendocrine cells.
+[https://en.wikipedia.org/wiki/Nav1.8 NaV1.8]: found in dorsal root ganglia.
+[https://en.wikipedia.org/wiki/Nav1.9 NaV1.9]: found in dorsal root ganglia.