Sandbox WWC3: Difference between revisions
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To see the selectivity filter, click <scene name='69/696300/Selectivity_pore/2'>here</scene>. THR 175 is blue, LEU 176 is yellow, GLU 177 is red and SER 178 is black. | To see the selectivity filter, click <scene name='69/696300/Selectivity_pore/2'>here</scene>. THR 175 is blue, LEU 176 is yellow, GLU 177 is red and SER 178 is black. | ||
===Alpha | ===Alpha Subunits=== | ||
There are nine different alpha subunits named NaV1.1 through NAV1.9<ref name = "sod"/>. Genes are SCN1 through SCN11<ref name = "sod"/>. You can find the structures and more information below. | There are nine different alpha subunits named NaV1.1 through NAV1.9<ref name = "sod"/>. Genes are SCN1 through SCN11<ref name = "sod"/>. You can find the structures and more information below. | ||
[https://en.wikipedia.org/wiki/Nav1.1 NaV1.1]: found in central and peripheral neurons and myocytes. Click <scene name='69/696300/Nav1_1/1'>here</scene> for the structure of the NaV1.1 inactivation gate. | * [https://en.wikipedia.org/wiki/Nav1.1 NaV1.1]: found in central and peripheral neurons and myocytes. Click <scene name='69/696300/Nav1_1/1'>here</scene> for the structure of the NaV1.1 inactivation gate. | ||
[https://en.wikipedia.org/wiki/Nav1.2 NaV1.2]: found in central and peripheral neurons. Click <scene name='69/696300/Nav1_2/1'>here</scene> for the structure of the NaV1.2 C terminal domain in complex with FGF13U and Ca2+/calmodulin. | * [https://en.wikipedia.org/wiki/Nav1.2 NaV1.2]: found in central and peripheral neurons. Click <scene name='69/696300/Nav1_2/1'>here</scene> for the structure of the NaV1.2 C terminal domain in complex with FGF13U and Ca2+/calmodulin. | ||
[https://en.wikipedia.org/wiki/SCN3A NaV1.3]: found in central and peripheral neurons and cardiac myocytes. | * [https://en.wikipedia.org/wiki/SCN3A NaV1.3]: found in central and peripheral neurons and cardiac myocytes. | ||
[https://en.wikipedia.org/wiki/Nav1.4 NaV1.4]: found in skeletal muscle. | * [https://en.wikipedia.org/wiki/Nav1.4 NaV1.4]: found in skeletal muscle. | ||
[https://en.wikipedia.org/wiki/Nav1.5 NaV1.5]: found in cardiac myocytes, uninnervated skeletal muscle, central neurons, gastrointestinal smooth muscle cells, and interstitial cells of Cajal. Click <scene name='69/696300/Nav1_5/1'>here</scene> for the structure of the NaV1.5 C terminal domain in complex with FGF12B and Ca2+/calmodulin. | * [https://en.wikipedia.org/wiki/Nav1.5 NaV1.5]: found in cardiac myocytes, uninnervated skeletal muscle, central neurons, gastrointestinal smooth muscle cells, and interstitial cells of Cajal. Click <scene name='69/696300/Nav1_5/1'>here</scene> for the structure of the NaV1.5 C terminal domain in complex with FGF12B and Ca2+/calmodulin. | ||
[https://en.wikipedia.org/wiki/SCN8A NaV1.6]: found in central neurons, dorsal root ganglia, peripheral neurons, heart and glial cells. | * [https://en.wikipedia.org/wiki/SCN8A NaV1.6]: found in central neurons, dorsal root ganglia, peripheral neurons, heart and glial cells. | ||
[https://en.wikipedia.org/wiki/Nav1.7 NaV1.7]: found in dorsal root ganglia, sympathetic neurons, Schwann cells and neuroendocrine cells. | * [https://en.wikipedia.org/wiki/Nav1.7 NaV1.7]: found in dorsal root ganglia, sympathetic neurons, Schwann cells and neuroendocrine cells. | ||
[https://en.wikipedia.org/wiki/Nav1.8 NaV1.8]: found in dorsal root ganglia. | * [https://en.wikipedia.org/wiki/Nav1.8 NaV1.8]: found in dorsal root ganglia. | ||
[https://en.wikipedia.org/wiki/Nav1.9 NaV1.9]: found in dorsal root ganglia. | * [https://en.wikipedia.org/wiki/Nav1.9 NaV1.9]: found in dorsal root ganglia. | ||
