Sandbox WWC3: Difference between revisions
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[[Image:Nature10238-f3.2.jpg]] | [[Image:Nature10238-f3.2.jpg]] | ||
This image shows the crystal structure of the selectivity filter <ref name= "crystal"/>. | |||
===α Subunits=== | ===α Subunits=== | ||
There are nine different α subunits named NaV1.1 through NAV1.9<ref name = "sod"/>. Genes are SCN1 through SCN11<ref name = "sod"/>. These structures differ in their sequence and kinetics<ref name = "sod"/>. As stated above, the α subunit is necessary to the function of the channel and can function independently of the β subunit. You can find the structures and more information below. | There are nine different α subunits named NaV1.1 through NAV1.9<ref name = "sod"/>. Genes are SCN1 through SCN11<ref name = "sod"/>. These structures differ in their sequence and kinetics<ref name = "sod"/>. As stated above, the α subunit is necessary to the function of the channel and can function independently of the β subunit. You can find the structures and more information below. | ||
* [https://en.wikipedia.org/wiki/Nav1.1 NaV1.1]: found in central and peripheral neurons and myocytes. Click <scene name='69/696300/Nav1_1/1'>here</scene> for the structure of the NaV1.1 inactivation gate. | * [https://en.wikipedia.org/wiki/Nav1.1 NaV1.1]: found in central and peripheral neurons and myocytes. Click <scene name='69/696300/Nav1_1/1'>here</scene> for the structure of the NaV1.1 inactivation gate<ref name = "sod"/>. | ||
* [https://en.wikipedia.org/wiki/Nav1.2 NaV1.2]: found in central and peripheral neurons. Click <scene name='69/696300/Nav1_2/1'>here</scene> for the structure of the NaV1.2 C terminal domain in complex with FGF13U and Ca2+/calmodulin. | * [https://en.wikipedia.org/wiki/Nav1.2 NaV1.2]: found in central and peripheral neurons. Click <scene name='69/696300/Nav1_2/1'>here</scene> for the structure of the NaV1.2 C terminal domain in complex with FGF13U and Ca2+/calmodulin<ref name = "sod"/>. | ||
* [https://en.wikipedia.org/wiki/SCN3A NaV1.3]: found in central and peripheral neurons and cardiac myocytes. | * [https://en.wikipedia.org/wiki/SCN3A NaV1.3]: found in central and peripheral neurons and cardiac myocytes<ref name = "sod"/>. | ||
* [https://en.wikipedia.org/wiki/Nav1.4 NaV1.4]: found in skeletal muscle. | * [https://en.wikipedia.org/wiki/Nav1.4 NaV1.4]: found in skeletal muscle<ref name = "sod"/>. | ||
* [https://en.wikipedia.org/wiki/Nav1.5 NaV1.5]: found in cardiac myocytes, uninnervated skeletal muscle, central neurons, gastrointestinal smooth muscle cells, and interstitial cells of Cajal. Click <scene name='69/696300/Nav1_5/1'>here</scene> for the structure of the NaV1.5 C terminal domain in complex with FGF12B and Ca2+/calmodulin. | * [https://en.wikipedia.org/wiki/Nav1.5 NaV1.5]: found in cardiac myocytes, uninnervated skeletal muscle, central neurons, gastrointestinal smooth muscle cells, and interstitial cells of Cajal. Click <scene name='69/696300/Nav1_5/1'>here</scene> for the structure of the NaV1.5 C terminal domain in complex with FGF12B and Ca2+/calmodulin<ref name = "sod"/>. | ||
* [https://en.wikipedia.org/wiki/SCN8A NaV1.6]: found in central neurons, dorsal root ganglia, peripheral neurons, heart and glial cells. | * [https://en.wikipedia.org/wiki/SCN8A NaV1.6]: found in central neurons, dorsal root ganglia, peripheral neurons, heart and glial cells<ref name = "sod"/>. | ||
* [https://en.wikipedia.org/wiki/Nav1.7 NaV1.7]: found in dorsal root ganglia, sympathetic neurons, Schwann cells and neuroendocrine cells. | * [https://en.wikipedia.org/wiki/Nav1.7 NaV1.7]: found in dorsal root ganglia, sympathetic neurons, Schwann cells and neuroendocrine cells<ref name = "sod"/>. | ||
* [https://en.wikipedia.org/wiki/Nav1.8 NaV1.8]: found in dorsal root ganglia. | * [https://en.wikipedia.org/wiki/Nav1.8 NaV1.8]: found in dorsal root ganglia<ref name = "sod"/>. | ||
* [https://en.wikipedia.org/wiki/Nav1.9 NaV1.9]: found in dorsal root ganglia. | * [https://en.wikipedia.org/wiki/Nav1.9 NaV1.9]: found in dorsal root ganglia<ref name = "sod"/>. | ||
===β Subunits=== | ===β Subunits=== | ||
Beta subunits function in channel gating, channel expression and form links to the cytoskeleton <ref name = "sod"/>. There are four different beta subunits named NaVβ1 through NaVβ4 and the genes are named SCN1B through SCN4B. | Beta subunits function in channel gating, channel expression and form links to the cytoskeleton <ref name = "sod"/>. There are four different beta subunits named NaVβ1 through NaVβ4 and the genes are named SCN1B through SCN4B<ref name = "sod"/>. | ||
*[https://en.wikipedia.org/wiki/SCN1B NaVβ1]: Assembles with NaV1.1 and NaV1.7 and found in central and peripheral neurons, skeletal muscle, heart and glial cells. | *[https://en.wikipedia.org/wiki/SCN1B NaVβ1]: Assembles with NaV1.1 and NaV1.7 and found in central and peripheral neurons, skeletal muscle, heart and glial cells<ref name = "sod"/>. | ||
*[https://en.wikipedia.org/wiki/SCN2B NaVβ2]: Assembles with NaV1.1, NaV1.2, NaV1.5 and NaV1.7 and found in central and peripheral neurons, heart and glial cells. | *[https://en.wikipedia.org/wiki/SCN2B NaVβ2]: Assembles with NaV1.1, NaV1.2, NaV1.5 and NaV1.7 and found in central and peripheral neurons, heart and glial cells<ref name = "sod"/>. | ||
*[https://en.wikipedia.org/wiki/SCN3B NaVβ3]: Assembles with NaV1.1, NaV1.3 and NaV1.5 and found in the central and peripheral neurons, adrenal gland and heart. | *[https://en.wikipedia.org/wiki/SCN3B NaVβ3]: Assembles with NaV1.1, NaV1.3 and NaV1.5 and found in the central and peripheral neurons, adrenal gland and heart<ref name = "sod"/>. | ||
*[https://en.wikipedia.org/wiki/SCN4B NaVβ4]: Assembles with NaV1.1, NaV1.2, and NaV1.5 and found in the heart, skeletal muscles, central and peripheral neurons. | *[https://en.wikipedia.org/wiki/SCN4B NaVβ4]: Assembles with NaV1.1, NaV1.2, and NaV1.5 and found in the heart, skeletal muscles, central and peripheral neurons<ref name = "sod"/>. | ||
