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<StructureSection load='1bka' size=' | <StructureSection load='1bka' size='400' side='right' caption='Human lactoferrin complex with oxalate and Fe+3 ion (PDB entry [[1bka]])' scene='45/455488/Cv/1'> | ||
== Function == | == Function == | ||
FunctionLactoferrin (LTF) is found in secretory fluids. LTF interacts with DNA, RNA, polysaccharides and heparin[1]. For detailed discussion of human lactoferrin see Human lactoferrin. RelevanceLTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin. It is a component of the immune system and has antimicrobial activity[2]. LTF can be used as a marker for inflammatory bowel disease[3]. Structural highlightsLTF is a bilobal protein with the N-terminal half and the C-terminal half called N-lobe and C-lobe. LTF binds with high affinity Fe+3 ion and an anion in both its N-lobe and its C-lobe[4]. The binding site is between the 2 domains of each lobe. The anion binds the Fe+3 in a 1,2 bidendate fashion. The anion binds the Fe+3 in a 1,2 bidendate fashion.
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Updated on 17-April-2016
This page was last modified 09:53, 17 April 2016.