Sandbox reserved 1169: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Neurotensin Receptor (NTSR1)== | ==Neurotensin Receptor (NTSR1)== | ||
<StructureSection load='4GRV2.pdb' size=' | <StructureSection load='4GRV2.pdb' size='500' frame= 'true' align='right' caption='Neurotensin G-Protein Coupled Receptor (PDB Codes [http://www.rcsb.org/pdb/explore/explore.do?structureId=4GRV 4GRV] and [http://www.rcsb.org/pdb/explore/explore.do?structureId=4XEE 4XEE])' scene='72/727765/Overall_structure/2'/>__NoTOC__ | ||
== Introduction == | == Introduction == | ||
The neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as [http://proteopedia.org/wiki/index.php/G_protein-coupled_receptor G protein-coupled receptors] (GPCRs) and responds to the 13 amino acid hormone [https://en.wikipedia.org/wiki/Neurotensin neurotensin (NTS)]. Currently around 800 G protein-coupled receptors have been identified and are hypothesized to be responsible for roughly 80% of [https://en.wikipedia.org/wiki/Signal_transduction signal transduction].<ref name="Millar">PMID:20019124</ref> GPCRs are involved in a vast array of physiological processes within the body that range from interactions with [https://en.wikipedia.org/wiki/Dopamine dopamine] to effects on secretion of bile in the intestines.<ref name="Gui">PMID:11208724</ref> <ref name="Binder">PMID:1173461</ref> Due to the vast array of functions that these proteins serve and their high abundance within the body, these proteins have become major drug targets.<ref name="Fang">PMID:23573662</ref> | The neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as [http://proteopedia.org/wiki/index.php/G_protein-coupled_receptor G protein-coupled receptors] (GPCRs) and responds to the 13 amino acid hormone [https://en.wikipedia.org/wiki/Neurotensin neurotensin (NTS)]. Currently around 800 G protein-coupled receptors have been identified and are hypothesized to be responsible for roughly 80% of [https://en.wikipedia.org/wiki/Signal_transduction signal transduction].<ref name="Millar">PMID:20019124</ref> GPCRs are involved in a vast array of physiological processes within the body that range from interactions with [https://en.wikipedia.org/wiki/Dopamine dopamine] to effects on secretion of bile in the intestines.<ref name="Gui">PMID:11208724</ref> <ref name="Binder">PMID:1173461</ref> Due to the vast array of functions that these proteins serve and their high abundance within the body, these proteins have become major drug targets.<ref name="Fang">PMID:23573662</ref> | ||
| Line 11: | Line 11: | ||
== Structure == | == Structure == | ||
=== Overall Structure === | === Overall Structure === | ||
[[Image:Nuerotensin membrane.jpg |100 px|left|thumb|Figure 1: Neurotensin Incorporation in Membrane ]] | [[Image:Nuerotensin membrane.jpg |100 px|left|thumb|Figure 1: Neurotensin Incorporation in Membrane ]] | ||
Like other G protein-coupled receptors, the neurotensin receptor is composed of 3 distinct regions. An extracellular binding site where neurotensin binds and causes a conformational change of the protein. A region containing <scene name='72/727765/Overall_structure/4'>7 transmembrane alpha helices</scene> (PDB code:[http://www.rcsb.org/pdb/explore/explore.do?structureId=4GRV 4GRV)] that transduce the signal from the extracellular side of the cell membrane to the intracellular side. Lastly, an intracellular region that when activated by a conformational change in the protein activates a [https://en.wikipedia.org/wiki/G_protein G protein] associated with this receptor. Currently no crystal structures of the inactive form of the neurotensin receptor available. Without a representation of the inactive form, the conformational changes caused by agonist binding are still not completely known. | Like other G protein-coupled receptors, the neurotensin receptor is composed of 3 distinct regions. An extracellular binding site where neurotensin binds and causes a conformational change of the protein. A region containing <scene name='72/727765/Overall_structure/4'>7 transmembrane alpha helices</scene> (PDB code:[http://www.rcsb.org/pdb/explore/explore.do?structureId=4GRV 4GRV)] that transduce the signal from the extracellular side of the cell membrane to the intracellular side. Lastly, an intracellular region that when activated by a conformational change in the protein activates a [https://en.wikipedia.org/wiki/G_protein G protein] associated with this receptor. Currently no crystal structures of the inactive form of the neurotensin receptor available. Without a representation of the inactive form, the conformational changes caused by agonist binding are still not completely known. | ||
