Sandbox Reserved 1160: Difference between revisions
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[[Image: Organic with clipped surface.png|200 px|left|thumb|'''Figure 2.''' Mavolugarent in its binding pocket of the 7TM region of mGLu5 Class C receptor. The binding pocket's surface is clipped in black with the substrate, mavolugarent, in red. The rest of the protein is colored in green. The binding pocket is present in the 7 Helix Transmembrane Domain that would be present in the phosolipid bilayer appearing as an intergral protein. The presence of mavolugarent inhibits the function of the metabotropic glutamate receptor.]] | [[Image: Organic with clipped surface.png|200 px|left|thumb|'''Figure 2.''' Mavolugarent in its binding pocket of the 7TM region of mGLu5 Class C receptor. The binding pocket's surface is clipped in black with the substrate, mavolugarent, in red. The rest of the protein is colored in green. The binding pocket is present in the 7 Helix Transmembrane Domain that would be present in the phosolipid bilayer appearing as an intergral protein. The presence of mavolugarent inhibits the function of the metabotropic glutamate receptor.]] | ||
The binding pocket, not to be confused with the glutamate binding site, represents an useful source of regulatory control. The binding pocket is only accessible by a relatively narrow (7 Å) <scene name='72/721531/Protien_sur/4'>entrance</scene><ref name="Dore" />. This small entrance severely restricts the access of both positive and negative allosteric regulators. | The binding pocket, not to be confused with the glutamate binding site, represents an useful source of regulatory control. The binding pocket is only accessible by a relatively narrow (7 Å) <scene name='72/721531/Protien_sur/4'>entrance</scene><ref name="Dore" />. This small entrance severely restricts the access of both positive and negative allosteric regulators. | ||
One such regulator, mavoglurant, is a | One such regulator, <scene name='72/721531/Mavo/1'>mavoglurant</scene>, is a | ||
Important Amino Acids<ref name="Dore" />: | Important Amino Acids<ref name="Dore" />: | ||
