Sandbox Reserved 1174: Difference between revisions

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===Pain===

When an injury occurs LPA is released in the body. It then ~~will~~ activate G-protein-coupled receptors. Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle). The LPA signaling will activate GTPase RhoA. Once activated Rho translocates to the plasma membrane. Rho will activate Rho kinase (ROCK). The actiavtion of ROCK is a required step in the pathway in the stimulation of neurotic pain. When ROCK was inhibited ~~it meant that the rest of~~ the pathway ~~would not work according to plan~~. Mice with the ~~deletation~~ of LPA1 receptors ~~were studied to see the role that LPA signaling played in pain. In a study done with mice, those without the LPA1 receptor~~ had lower levels of pain.<ref name= "Inoue"> DOI:10.1038/nm1060 </ref>. Another use of LPA is it can help in stimulation of cell migration <ref name= "Moolenaar"/>.

When an injury occurs LPA is released in the body. LPA will then activate G-protein-coupled receptors. Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle). The LPA signaling will activate GTPase RhoA. Once activated Rho translocates to the plasma membrane. Rho will activate Rho kinase (ROCK). The actiavtion of ROCK is a required step in the pathway in the stimulation of neurotic pain. When ROCK was inhibited the remaining pathway no longer functioned normally. Mice with the deletion of LPA1 receptors had lower levels of pain <ref name= "Inoue"> DOI:10.1038/nm1060 </ref>. Another use of LPA is it can help in stimulation of cell migration <ref name= "Moolenaar"/>.

=== Fibrosis ===

Sandbox Reserved 1174: Difference between revisions

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@@ Line 50: / Line 50: @@
 ===Pain===
-When an injury occurs LPA is released in the body.  It then will activate G-protein-coupled receptors.  Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle).  The LPA signaling will activate GTPase RhoA.  Once activated Rho translocates to the plasma membrane.  Rho will activate Rho kinase (ROCK).  The actiavtion of ROCK is a required step in the pathway in the stimulation of neurotic pain.  When ROCK was inhibited it meant that the rest of the pathway would not work according to plan.  Mice with the deletation of LPA<sub>1</sub> receptors were studied to see the role that LPA signaling played in pain.  In a study done with mice, those without the LPA<sub>1</sub> receptor had lower levels of pain.<ref name= "Inoue"> DOI:10.1038/nm1060 </ref>.  Another use of LPA is it can help in stimulation of cell migration <ref name= "Moolenaar"/>.
+When an injury occurs LPA is released in the body.  LPA will then activate G-protein-coupled receptors.  Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle).  The LPA signaling will activate GTPase RhoA.  Once activated Rho translocates to the plasma membrane.  Rho will activate Rho kinase (ROCK).  The actiavtion of ROCK is a required step in the pathway in the stimulation of neurotic pain.  When ROCK was inhibited the remaining pathway no longer functioned normally.  Mice with the deletion of LPA<sub>1</sub> receptors had lower levels of pain <ref name= "Inoue"> DOI:10.1038/nm1060 </ref>.  Another use of LPA is it can help in stimulation of cell migration <ref name= "Moolenaar"/>.
 === Fibrosis ===