Sandbox Reserved 1160: Difference between revisions

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The functionality of the mGlu5 receptor is determined by conformational changes throughout multiple domains. mGlu5 will bind glutamate through its extracellular Venus flytrap domain and the signal will be transduced across the membrane to a heterotrimeric G protein, which will ultimately lead to calcium release and the activation of [[PKC]]<ref name="Wu" />. The signal is relayed through a Gq/11 pathway<ref name="Dore" />. Activated PKC will elicit a excitory post-synaptic response and modulate long term potentiation<ref name="Wu" />.

Human mGlu5 is found throughout the central nervous system. Areas containing high concentrations of mGlu5 are often involved in emotional processing and higher cognition<ref name="Niswender" />. The localization of mGlu5 in the CNS and the presence of multiple domains makes mGlu5 an excellent target for treating neurological conditions including: schizophrenia,[http://www.fragilex.org/fragile-x/fragile-x-syndrome/ Fragile X], depression, anxiety, and Alzheimer's disease<ref name="Wu" />.

Human mGlu5 is found throughout the central nervous system. Areas containing high concentrations of mGlu5 are often involved in emotional processing and higher cognition<ref name="Niswender" />. The localization of mGlu5 in the CNS and the presence of multiple domains makes mGlu5 an excellent target for treating neurological conditions including: schizophrenia,[http://www.fragilex.org/fragile-x/fragile-x-syndrome/ Fragile X], [http://www.en.wikipedia.org/wiki/Depression_(mood)depression], [http://www.en.wikipedia.org/wiki/Anxiety_disorder anxiety], and [http://www.en.wikipedia.org/wiki/Alzheimer's_disease Alzheimer's disease]<ref name="Wu" />.

== Discovery ==

Sandbox Reserved 1160: Difference between revisions

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 The functionality of the mGlu5 receptor is determined by conformational changes throughout multiple domains. mGlu5 will bind glutamate through its extracellular Venus flytrap domain and the signal will be transduced across the membrane to a heterotrimeric G protein, which will ultimately lead to calcium release and the activation of [[PKC]]<ref name="Wu" />. The signal is relayed through a Gq/11 pathway<ref name="Dore" />. Activated PKC will elicit a excitory post-synaptic response and modulate long term potentiation<ref name="Wu" />.
-Human mGlu5 is found throughout the central nervous system. Areas containing high concentrations of mGlu5 are often involved in emotional processing and higher cognition<ref name="Niswender" />. The localization of mGlu5 in the CNS and the presence of multiple domains makes mGlu5 an excellent target for treating neurological conditions including: schizophrenia,[http://www.fragilex.org/fragile-x/fragile-x-syndrome/ Fragile X], depression, anxiety, and Alzheimer's disease<ref name="Wu" />.
+Human mGlu5 is found throughout the central nervous system. Areas containing high concentrations of mGlu5 are often involved in emotional processing and higher cognition<ref name="Niswender" />. The localization of mGlu5 in the CNS and the presence of multiple domains makes mGlu5 an excellent target for treating neurological conditions including: schizophrenia,[http://www.fragilex.org/fragile-x/fragile-x-syndrome/ Fragile X], [http://www.en.wikipedia.org/wiki/Depression_(mood)depression], [http://www.en.wikipedia.org/wiki/Anxiety_disorder anxiety], and [http://www.en.wikipedia.org/wiki/Alzheimer's_disease Alzheimer's disease]<ref name="Wu" />.
 == Discovery ==