Sandbox Reserved 1174: Difference between revisions
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=== Binding Pocket === | === Binding Pocket === | ||
The ligand shown in this structure, ONO-9780307, has a similar structure to LPA, and was bound to LPA<sub>1</sub> for crystallization to visualize the binding pocket. <ref name= "Moolenaar" /> The <scene name='72/721545/Ligand/2'>binding pocket</scene> for LPA consists of both polar and nonpolar residues. <scene name='72/721545/All_polar_interactions/7'>Polar</scene> residues are located on the N terminus and within the binding pocket. | The ligand shown in this structure, ONO-9780307, has a similar structure to LPA, and was bound to LPA<sub>1</sub> for crystallization to visualize the binding pocket. <ref name= "Moolenaar" /> The <scene name='72/721545/Ligand/2'>binding pocket</scene> for LPA consists of both polar and nonpolar residues. <scene name='72/721545/All_polar_interactions/7'>Polar</scene> residues are located on the N terminus and within the binding pocket. A <scene name='72/721545/Hydrophobic_pocket/4'>hydrophobic pocket</scene> also interacts with the long acyl chain of LPA. The shape and polarity of the binding pocket makes it specific for molecules with a polar head and long hydrophobic tail shaped like LPA. | ||
LPA is synthesized extracellularly and enters the binding pocket from the extracellular space near the N terminus, the exact location is not known. When LPA binds, the G protein bound to the intracellular region of LPA<sub>1</sub> is activated. This G protein then signals the cell, mainly for survival and proliferation. | LPA is synthesized extracellularly and enters the binding pocket from the extracellular space near the N terminus, the exact location is not known. When LPA binds, the G protein bound to the intracellular region of LPA<sub>1</sub> is activated. This G protein then signals the cell, mainly for survival and proliferation. | ||
