Sandbox Reserved 1165: Difference between revisions

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[[Image:Screen_Shot_2016-03-22_at_5.28.03_PM.png|(|):|425 px|center|thumb|'''Figure 3: Binding Pocket Residues:''' Residues with side chains of carbon(utilizing the [https://en.wikipedia.org/wiki/Hydrophobic_effect hydrophobic effect]) are shown in green and side chains containing oxygen ([https://en.wikipedia.org/wiki/Hydrophile hydrophilic]) are shown in red. The properties of hydrophobicity and hydrophilicity of the residues create the [https://en.wikipedia.org/wiki/Ligand_%28biochemistry%29#Receptor.2Fligand_binding_affinity binding affinity] of glucagon.<ref name="Ligands">PMID: 21542831</ref> This image depicts the open conformation of GCGR.]]  
[[Image:Screen_Shot_2016-03-22_at_5.28.03_PM.png|(|):|425 px|center|thumb|'''Figure 3: Binding Pocket Residues:''' Residues with side chains of carbon(utilizing the [https://en.wikipedia.org/wiki/Hydrophobic_effect hydrophobic effect]) are shown in green and side chains containing oxygen ([https://en.wikipedia.org/wiki/Hydrophile hydrophilic]) are shown in red. The properties of hydrophobicity and hydrophilicity of the residues create the [https://en.wikipedia.org/wiki/Ligand_%28biochemistry%29#Receptor.2Fligand_binding_affinity binding affinity] of glucagon.<ref name="Ligands">PMID: 21542831</ref> This image depicts the open conformation of GCGR.]]  


The [https://en.wikipedia.org/wiki/Residue_(chemistry) residues] in the binding pocket that are in direct contact with the glucagon molecule are [https://en.wikipedia.org/wiki/Chemical_polarity polar] (utilizing the attraction of opposite charges or (https://en.wikipedia.org/wiki/Dipole dipoles] for glucagon binding) or are hydrophobic (utilizing the hydrophobic effect). The [https://en.wikipedia.org/wiki/Active_site binding site] location of the hormone peptide ligand has been identified, and the N-terminus of glucagon is known to bind partly with the ECD while the rest of glucagon binds deep into the <scene name='72/721535/Binding_pocket_orange/1'>binding pocket</scene> (Figure 3). The [https://en.wikipedia.org/wiki/Amino_acid amino acids] at the N-terminus of the class B 7TM have the ability to form [https://en.wikipedia.org/wiki/Hydrogen_bond hydrogen bonds] and [https://en.wikipedia.org/wiki/Ionic_bonding ionic interactions], which can be seen in the [https://en.wikipedia.org/wiki/Peptide_sequence amino acid sequence] of glucagon (Figure 4). <ref name="Sequence">PMID: 11946536</ref>
The [https://en.wikipedia.org/wiki/Residue_(chemistry) residues] in the binding pocket that are in direct contact with the glucagon molecule are [https://en.wikipedia.org/wiki/Chemical_polarity polar] (utilizing the attraction of opposite charges or (https://en.wikipedia.org/wiki/Dipole dipoles] for glucagon binding) or are hydrophobic (utilizing the hydrophobic effect). The [https://en.wikipedia.org/wiki/Active_site binding site] location of the hormone peptide ligand has been identified, and the N-terminus of glucagon is known to bind partly with the ECD while the rest of glucagon binds deep into the binding pocket (Figure 3). The [https://en.wikipedia.org/wiki/Amino_acid amino acids] at the N-terminus of the class B 7TM have the ability to form [https://en.wikipedia.org/wiki/Hydrogen_bond hydrogen bonds] and [https://en.wikipedia.org/wiki/Ionic_bonding ionic interactions], which can be seen in the [https://en.wikipedia.org/wiki/Peptide_sequence amino acid sequence] of glucagon (Figure 4). <ref name="Sequence">PMID: 11946536</ref>


    
    
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