Sandbox Reserved 1167: Difference between revisions
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==== Binding Pocket ==== | ==== Binding Pocket ==== | ||
[[Image:Labeled_Binding_Pocket.png|200 px|left|thumb|'''Figure 1. GCGR Binding Pocket.''' A cross-section of the GCGR binding pocket shows its width and depth]]The class B GPCR has the widest and longest <scene name='72/721538/Binding_pocket/1'>binding pocket</scene> of all other classes of GPCRs. The distance between the EC tips of Helicies II and VI as well as between the tips of Helicies III and VII are some of the largest among the GPCRs<ref name="structure_article" />. As a result, the [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820480/bin/nihms495648f2.jpg binding cavity] of GCGR is located deeper inside the | [[Image:Labeled_Binding_Pocket.png|200 px|left|thumb|'''Figure 1. GCGR Binding Pocket.''' A cross-section of the GCGR binding pocket shows its width and depth]]The class B GPCR has the widest and longest <scene name='72/721538/Binding_pocket/1'>binding pocket</scene> of all other classes of GPCRs. The distance between the EC tips of Helicies II and VI as well as between the tips of Helicies III and VII are some of the largest among the GPCRs<ref name="structure_article" />. As a result, the [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820480/bin/nihms495648f2.jpg binding cavity] of GCGR is located deeper inside the receptor, meaning glucagon binds much closer to the cell membrane. | ||
====Other Unique Structural Features ==== | ====Other Unique Structural Features ==== | ||
