Sandbox Reserved 1167: Difference between revisions

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== Function ==

The glucagon receptor plays an important role in glucose homeostasis. During times of fasting (or low blood sugar) the pancreas produces glucagon to activate the GCGR in the liver. The [http://www.nature.com/nature/journal/v499/n7459/fig_tab/nature12393_F5.html binding of glucagon] ~~stimulates [https://en~~.~~wikipedia~~.~~org/wiki/Gluconeogenesis gluconeogenesis]~~, ~~through [https://en.wikipedia.org/wiki/Adenylyl_cyclase~~ adenylate cyclase~~] that~~ initiates ~~[https://en.wikipedia.org/wiki/Protein_kinase_A~~ protein kinase A] (PKA) activity~~<ref>PMID:25674162</ref>~~. ~~This pathway synthesizes glucose~~, ~~elevating~~ blood sugar levels.

The glucagon receptor plays an important role in glucose homeostasis. During times of fasting (or low blood sugar) the pancreas produces glucagon to activate the GCGR in the liver. The [http://www.nature.com/nature/journal/v499/n7459/fig_tab/nature12393_F5.html binding of glucagon] to the extracellular side of GCGR leads to the activation of the receptor. On the intracellular side, upon this activation, a guanine diphosphate (GDP) is exchanged for a guanine triphosphate (GTP) - which, in turn, activates adenylate cyclase. Converting adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP), adenylate cyclase initiates protein kinase A (PKA) activity, which releases glucose into the blood stream. Overall, activation of the GCGR elevates blood sugar levels.

Sandbox Reserved 1167: Difference between revisions

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Revision as of 07:58, 19 April 2016 view source Alexis Coulis (talk \| contribs) 137 edits No edit summary ← Older edit		Revision as of 08:14, 19 April 2016 view source Alexis Coulis (talk \| contribs) 137 edits No edit summary Newer edit →
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	== Function ==		== Function ==

	The glucagon receptor plays an important role in glucose homeostasis. During times of fasting (or low blood sugar) the pancreas produces glucagon to activate the GCGR in the liver. The [http://www.nature.com/nature/journal/v499/n7459/fig_tab/nature12393_F5.html binding of glucagon] ~~stimulates [https://en~~.~~wikipedia~~.~~org/wiki/Gluconeogenesis gluconeogenesis]~~, ~~through [https://en.wikipedia.org/wiki/Adenylyl_cyclase~~ adenylate cyclase~~] that~~ initiates ~~[https://en.wikipedia.org/wiki/Protein_kinase_A~~ protein kinase A] (PKA) activity~~<ref>PMID:25674162</ref>~~. ~~This pathway synthesizes glucose~~, ~~elevating~~ blood sugar levels.		The glucagon receptor plays an important role in glucose homeostasis. During times of fasting (or low blood sugar) the pancreas produces glucagon to activate the GCGR in the liver. The [http://www.nature.com/nature/journal/v499/n7459/fig_tab/nature12393_F5.html binding of glucagon] to the extracellular side of GCGR leads to the activation of the receptor. On the intracellular side, upon this activation, a guanine diphosphate (GDP) is exchanged for a guanine triphosphate (GTP) - which, in turn, activates adenylate cyclase. Converting adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP), adenylate cyclase initiates protein kinase A (PKA) activity, which releases glucose into the blood stream. Overall, activation of the GCGR elevates blood sugar levels.