MECDP synthase: Difference between revisions
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{{STRUCTURE_1gx1| PDB=1gx1 | SIZE=400| SCENE= |right|CAPTION=Se-Met MECDP synthase trimer complex with CDP (stick model), sulfate, Mn+2 (purple) and Zn+2 (grey) ion, [[1gx1]] }} | {{STRUCTURE_1gx1| PDB=1gx1 | SIZE=400| SCENE= |right|CAPTION=Se-Met MECDP synthase trimer complex with CDP (stick model), sulfate, Mn+2 (purple) and Zn+2 (grey) ion, [[1gx1]] }} | ||
== Function == | |||
'''MECDP synthase''' (MECPS) participates in mevalonate-independent steroid biosynthesis. It converts 2-phospho-4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol (2P-CDME) to 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate (MECP) and CMP. MECPS contains metal binding sites which are required for catalysis<ref>PMID:11786530</ref>. | |||
== Relevance == | |||
MECPS is a potential antimalarial drug target<ref>PMID:12499535</ref>. | |||
== Structural highlights == | |||
MECPS active site is located in a cleft between 2 subunits and contains the metal ions<ref>PMID:11997478</ref>. | |||
==3D structures of MECDP synthase== | ==3D structures of MECDP synthase== | ||
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**[[1h48]] - EcMECPS + MECP + CMP + geranyl diphosphate + Mn + Zn<br /> | **[[1h48]] - EcMECPS + MECP + CMP + geranyl diphosphate + Mn + Zn<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
