Sandbox Reserved 1181: Difference between revisions
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[[Image:Movie Frame 6.png |100 px|left|thumb|Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.]] | [[Image:Movie Frame 6.png |100 px|left|thumb|Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.]] | ||
[[Image:Movie_Frame_7.png|175 px|left|thumb|Fig. 14: Distance measurement of GCGR 7TMD Y138-D362 of 19-20 angstroms and labeled with complimentary glucagon interaction residues.]] | |||
[[Image:H1___Y10_with_measurement.png|175 px|right|thumb|Fig. 15: Distance measurement of H1-Y10 of 22-24 angstroms and labeled with complimentary GCGR 7TMD residue interactions.]] | |||
===Future research direction=== | |||
Research for Class A GPCRs is much more extensive than for its secretin, class B counterparts, although class B is proving to be a worthwhile to invest researching. The challenge of class B stabilization, expression, and molecular size , has made class B GPCRs particularly hard to assay. Biochemical research has increased in the class B specifications, because it has been realized that receptors can be modulated by more than the agonist and antagonists present in vivo. Leading research consists of a complex interwoven scheme of equilibria manipulation in multi-receptor conformations. <ref name="Salon 2011"/> | |||
