Sandbox Reserved 1176: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Danny Cotter (talk | contribs) No edit summary |
Danny Cotter (talk | contribs) No edit summary |
||
| Line 12: | Line 12: | ||
One key residue in this pocket is a Phenylalanine at position 358, which takes part in a network of hydrophobic stacking interactions. <ref name="SPGP/> These interactions stabilize the Trp321 and Tyr324 residues allowing Tyr324 to interact with the '''[https://en.wikipedia.org/wiki/C-terminus C-terminal]''' | One key residue in this pocket is a Phenylalanine at position 358, which takes part in a network of hydrophobic stacking interactions. <ref name="SPGP/> These interactions stabilize the Trp321 and Tyr324 residues allowing Tyr324 to interact with the '''[https://en.wikipedia.org/wiki/C-terminus C-terminal]''' | ||
<scene name='72/721547/Ligand_protein_interactions/7'>Leu13 residue of the NTS ligand</scene> | <scene name='72/721547/Ligand_protein_interactions/7'>Leu13 residue of the NTS ligand</scene> | ||
via '''[https://en.wikipedia.org/wiki/Van_der_Waals_force Van der Waals interactions]''' . <ref name="SONT"/> <ref name="SPGP"/> | via '''[https://en.wikipedia.org/wiki/Van_der_Waals_force Van der Waals interactions]''' .<ref name="SONT"/><ref name="SPGP"/> | ||
Without the hydrophobic stacking interactions that are facilitated by the Phe358, this binding interaction would be destabilized. Trp321 also participates in these stacking interactions and serves as the boundary between the ligand binding pocket and the sodium binding pocket. <ref name="SPGP"/> | Without the hydrophobic stacking interactions that are facilitated by the Phe358, this binding interaction would be destabilized. Trp321 also participates in these stacking interactions and serves as the boundary between the ligand binding pocket and the sodium binding pocket. <ref name="SPGP"/> | ||
