Sandbox Reserved 1176: Difference between revisions

===Na⁺ Binding Pocket===

<scene name='72/721548/Trp321/1'>Trp321</scene>, which is positioned at the bottom of the <scene name='72/721547/Hydrophobic_binding_pocket/5'>hydrophobic binding pocket</scene>, sets the top of the <scene name='72/721548/Na_bind_pocket/12'> sodium binding pocket</scene>. The Na⁺ ion binding pocket acts as a negative allosteric site for G protein activity <ref name="SPGP"/>. When Na⁺ enters the Na⁺ ion binding pocket, it coordinates with Asp95, Gln131, Ser135, and Asp113, decreasing the signaling activity of NTSR1 <ref name="SPGP"/>. When NTSR1 is in its active state, the Na⁺ ion binding pocket is collapsed, preventing the regulations of protein activity through a Na⁺ ion, as the Na⁺ ion is unable to be coordinated by a salt bridge to Asp113 (Figure 2). The side chain atoms of Asp113 form a '''[https://en.wikipedia.org/wiki/Hydrogen_bond hydrogen bond]''' network with Thr156, Ser361, Ser362, and Gln365 instead, which prevents the coordination of a Na⁺ ion<ref name ="SPGP"/> (Figure 2).