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== Function ==

As previously stated, the function of MAO-A is to deaminate 5-hydroxytryptamine (5-HT), epinephrine, norepinephrine, dopamine, tyramine, and N,N-dimethyltryptamine (DMT). When neurons release neurotransmitters into the synaptic cleft to bind to a receptor, some of the neurotransmitters do not bind to the receptor and are not re-uptaken. The monoamine oxidase enzymes are responsible for oxidizing some of these "free" neurotransmitters in an attempt to prevent their binding to unintended receptors, potentially causing deleterious side effects; they are also responsible for maintaining a steady ~~balance~~ of certain neurotransmitters.

As previously stated, the function of MAO-A is to deaminate 5-hydroxytryptamine (5-HT), epinephrine, norepinephrine, dopamine, tyramine, and N,N-dimethyltryptamine (DMT). When neurons release neurotransmitters into the synaptic cleft to bind to a receptor, some of the neurotransmitters do not bind to the receptor and are not re-uptaken. The monoamine oxidase enzymes are responsible for oxidizing some of these "free" neurotransmitters in an attempt to prevent their binding to unintended receptors, potentially causing deleterious side effects; they are also responsible for maintaining a steady state of certain neurotransmitters.

Although MAO-A is found concentrated in catecholaminergic neurons, it is primarily found in the digestive system, while MAO-B is found more abundantly in the brain. This poses a problem in treating diseases caused by an imbalance in MAO-B. Since the binding site of both enzymes are very similar, many monoamine oxidase inhibitors (MAOIs)will inhibit both isoforms of monoamine oxidase rather than just the one causing the problem. MAOIs are among the most effective anti-depressants available, however, many inhibit MAO-A alongside the target MAO-B, which results in the need to be on a very strict diet while on MAOIs. The diet requires that the patient avoid:

There are two polymorphisms of the MAOA gene that are prevalent in humans, the low and high activity forms of MAO-A.

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 == Function ==
-As previously stated, the function of MAO-A is to deaminate 5-hydroxytryptamine (5-HT), epinephrine, norepinephrine, dopamine, tyramine, and N,N-dimethyltryptamine (DMT). When neurons release neurotransmitters into the synaptic cleft to bind to a receptor, some of the neurotransmitters do not bind to the receptor and are not re-uptaken. The monoamine oxidase enzymes are responsible for oxidizing some of these "free" neurotransmitters in an attempt to prevent their binding to unintended receptors, potentially causing deleterious side effects; they are also responsible for maintaining a steady balance of certain neurotransmitters.
+As previously stated, the function of MAO-A is to deaminate 5-hydroxytryptamine (5-HT), epinephrine, norepinephrine, dopamine, tyramine, and N,N-dimethyltryptamine (DMT). When neurons release neurotransmitters into the synaptic cleft to bind to a receptor, some of the neurotransmitters do not bind to the receptor and are not re-uptaken. The monoamine oxidase enzymes are responsible for oxidizing some of these "free" neurotransmitters in an attempt to prevent their binding to unintended receptors, potentially causing deleterious side effects; they are also responsible for maintaining a steady state of certain neurotransmitters.
+Although MAO-A is found concentrated in catecholaminergic neurons, it is primarily found in the digestive system, while MAO-B is found more abundantly in the brain. This poses a problem in treating diseases caused by an imbalance in MAO-B. Since the binding site of both enzymes are very similar, many monoamine oxidase inhibitors (MAOIs)will inhibit both isoforms of monoamine oxidase rather than just the one causing the problem.  MAOIs are among the most effective anti-depressants available, however, many inhibit MAO-A alongside the target MAO-B, which results in the need to be on a very strict diet while on MAOIs. The diet requires that the patient avoid:
 There are two polymorphisms of the MAOA gene that are prevalent in humans, the low and high activity forms of MAO-A.