Sandbox 465: Difference between revisions

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== Function ==

Serine-threonine kinase (STK11) is a tumor suppressor gene that plays an important role in regulating cell growth, cell polarity and apoposis. It controls the activity of adenine monophosphate-activated protein kinase (AMPK). STK11 is regulated by the pseudokinase STRADA and the protein MO25. Both STRADA and MO25 allosterically promote the activation of STK11, which is also stabilized by MO25 interacting with the STK11 activation loop (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518268/). The STK11 alpha helix is rotated into a closed conformation, conserving salt bridge between <scene name='72/728131/Lys/2'>lys78</scene> and <scene name='72/728131/Glu/3'>glu98</scene> . This is where the active conformation is formed (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518268/). STK11 facilitates cell cycle arrest through induction of cyclin-dependent kinase inhibitor p21WAF1, through a p53-dependent process. (http://www.nature.com/modpathol/journal/v16/n7/full/3880825a.html#bib13) P21 inhibits apoptosis and may promote cell proliferation in some tumors (http://www.ncbi.nlm.nih.gov/pubmed/19449443). STK11 also interacts with brahma-related gene-1 (BRG1), an ATpase that is associated with SWI/SNF chromatin-remodeling complexes. Exogenous express of brg1 is able to induce cell cycle arrest and loss of cell power of division and growth in a retinoblastoma-dependent fashion. The tumor suppression function of STK11 lies within its ability to affect the cell cycle proliferation. (http://www.nature.com/modpathol/journal/v16/n7/full/3880825a.html#bib13)

Serine-threonine kinase (STK11) is a tumor suppressor gene that plays an important role in regulating cell growth, cell polarity and apoptosis. It controls the activity of adenine monophosphate-activated protein kinase (AMPK). STK11 is regulated by the pseudokinase STRADA and the protein MO25. Both STRADA and MO25 allosterically promote the activation of STK11, which is also stabilized by MO25 interacting with the STK11 activation loop <ref> PMID: 19892943 </ref> The STK11 alpha helix is rotated into a closed conformation, conserving salt bridge between <scene name='72/728131/Lys/2'>lys78</scene> and <scene name='72/728131/Glu/3'>glu98</scene> . This is where the active conformation is formed <ref> PMID: 19892943 </ref> STK11 facilitates cell cycle arrest through induction of cyclin-dependent kinase inhibitor p21WAF1, through a p53-dependent process <ref name="loss"> PMID: 12861065</ref>

P21 inhibits apoptosis and may promote cell proliferation in some tumors <ref> PMID: 19449443 </ref> STK11 also interacts with brahma-related gene-1 (BRG1), an ATpase that is associated with SWI/SNF chromatin-remodeling complexes. Exogenous express of brg1 is able to induce cell cycle arrest and loss of cell power of division and growth in a retinoblastoma-dependent fashion. The tumor suppression function of STK11 lies within its ability to affect the cell cycle proliferation.

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Sandbox 465: Difference between revisions

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 == Function ==
-Serine-threonine kinase (STK11) is a tumor suppressor gene that plays an important role in regulating cell growth, cell polarity and apoposis.  It controls the activity of adenine monophosphate-activated protein kinase (AMPK). STK11 is regulated by the pseudokinase STRADA and the protein MO25. Both STRADA and MO25 allosterically promote the activation of  STK11, which is also stabilized by MO25 interacting with the STK11 activation loop  (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518268/). The STK11 alpha helix is rotated into a closed conformation, conserving salt bridge between <scene name='72/728131/Lys/2'>lys78</scene> and <scene name='72/728131/Glu/3'>glu98</scene> . This is where the active conformation is formed (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518268/). STK11 facilitates cell cycle arrest through induction of cyclin-dependent kinase inhibitor p21WAF1, through a p53-dependent process. (http://www.nature.com/modpathol/journal/v16/n7/full/3880825a.html#bib13) P21 inhibits apoptosis and may promote cell proliferation in some tumors (http://www.ncbi.nlm.nih.gov/pubmed/19449443).  STK11 also interacts with brahma-related gene-1 (BRG1), an ATpase that is associated with SWI/SNF chromatin-remodeling complexes. Exogenous express of brg1 is able to induce cell cycle arrest and loss of cell power of division and growth in a retinoblastoma-dependent fashion.  The tumor suppression function of STK11 lies within its ability to affect the cell cycle proliferation. (http://www.nature.com/modpathol/journal/v16/n7/full/3880825a.html#bib13)
+Serine-threonine kinase (STK11) is a tumor suppressor gene that plays an important role in regulating cell growth, cell polarity and apoptosis.  It controls the activity of adenine monophosphate-activated protein kinase (AMPK). STK11 is regulated by the pseudokinase STRADA and the protein MO25. Both STRADA and MO25 allosterically promote the activation of  STK11, which is also stabilized by MO25 interacting with the STK11 activation loop  <ref> PMID: 19892943 </ref> The STK11 alpha helix is rotated into a closed conformation, conserving salt bridge between <scene name='72/728131/Lys/2'>lys78</scene> and <scene name='72/728131/Glu/3'>glu98</scene> . This is where the active conformation is formed <ref> PMID: 19892943 </ref> STK11 facilitates cell cycle arrest through induction of cyclin-dependent kinase inhibitor p21WAF1, through a p53-dependent process <ref name="loss"> PMID: 12861065</ref>
+P21 inhibits apoptosis and may promote cell proliferation in some tumors <ref> PMID: 19449443 </ref>  STK11 also interacts with brahma-related gene-1 (BRG1), an ATpase that is associated with SWI/SNF chromatin-remodeling complexes. Exogenous express of brg1 is able to induce cell cycle arrest and loss of cell power of division and growth in a retinoblastoma-dependent fashion.  The tumor suppression function of STK11 lies within its ability to affect the cell cycle proliferation.
+<ref name="loss" />
 ----