Sandbox WWC11: Difference between revisions
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[[Image:Heme_site.JPG]] | [[Image:Heme_site.JPG]] | ||
Figure 1. Depicts key amino acids in stabilization of heme in myeloperoxidase. <ref name="Myeloperoxidase">PMID:26884610</ref> | Figure 1. Depicts key amino acids in stabilization of heme in myeloperoxidase. <ref name="Myeloperoxidase">PMID:26884610</ref> | ||
'''Function''' | '''Function''' | ||
Image | |||
[[Image:Enzymatic_processes_of_myeloperoxidase.JPG]] | |||
Figure 2. The Enzymatic Activity of Myeloperoxidase. <ref name="Myeloperoxidase">PMID:21297906</ref> | Figure 2. The Enzymatic Activity of Myeloperoxidase. <ref name="Myeloperoxidase">PMID:21297906</ref> | ||
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Now that the enzymatic properties of myeloperoxidase has been explore, it is time to turn to the bigger picture. These enzymes are stored in the subtype of leukocytes(white blood cells) called neutrophils. These are thought to be one of the first cells types at the site of infection.<ref name="Neutrophil">PMID:26904693</ref> An outline of the immune response of neutrophil, specifically highlighting MPO's role, can be seen in Figure 3 below. There are two paths seen in this figure. In the first the bacteria gets taken up by neutrophil extracellular traps or NETs and then destroyed by the hypohalogous acids. The second path shows the MPO being released, signaled by the dendrite cells(DCs), and helping to destroy the pathogen.<ref name="Neutrophil">PMID:26904693</ref> ANCA stands for anti-neutrophil cytoplasmic antibody. The myeloperoxidase have a range of function that are steered by the neutophil cells. This intense oxidative power is very helpful when targeted to foreign bodies. However, as discussed in the next section, it can very destructive if release on our own tissue. | Now that the enzymatic properties of myeloperoxidase has been explore, it is time to turn to the bigger picture. These enzymes are stored in the subtype of leukocytes(white blood cells) called neutrophils. These are thought to be one of the first cells types at the site of infection.<ref name="Neutrophil">PMID:26904693</ref> An outline of the immune response of neutrophil, specifically highlighting MPO's role, can be seen in Figure 3 below. There are two paths seen in this figure. In the first the bacteria gets taken up by neutrophil extracellular traps or NETs and then destroyed by the hypohalogous acids. The second path shows the MPO being released, signaled by the dendrite cells(DCs), and helping to destroy the pathogen.<ref name="Neutrophil">PMID:26904693</ref> ANCA stands for anti-neutrophil cytoplasmic antibody. The myeloperoxidase have a range of function that are steered by the neutophil cells. This intense oxidative power is very helpful when targeted to foreign bodies. However, as discussed in the next section, it can very destructive if release on our own tissue. | ||
Image | [[Image:Neutrophil_Process.JPG]] | ||
Figure 3. The immune response of neutrophils with specific emphasis on myeloperoxidase.<ref name="Neutrophil">PMID:26904693</ref> | Figure 3. The immune response of neutrophils with specific emphasis on myeloperoxidase.<ref name="Neutrophil">PMID:26904693</ref> | ||
