Sandbox Reserved 433: Difference between revisions
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The assembly composition of the 2yly protein is a homodimer. (Quaternary structure) | The assembly composition of the 2yly protein is a homodimer. (Quaternary structure) | ||
The DNA Binding domain is located in the C region, which is highly conserved. The ligand binding domain is located at the C terminus in the E and F regions. | The DNA Binding domain is located in the C region, which is highly conserved. The ligand binding domain is located at the C terminus in the E and F regions. The ligand binding domain is often called the “three-layered anti-parallel α helical sandwich” because it contains 12 alpha helices along with one beta hairpin. Sites for dimerization and nuclear localization are located in the the D region, which is poorly conserved. Both ERα and ERβ have several splice variants, with ERα having over 20 and ERβ having 5. | ||
The 2yly protein's secondary structure consists of | The 2yly protein's secondary structure consists of mostly alpha helices (148 residues) and only two beta strands (6 residues) on the outside of the receptor shown below with the alpha helices showing polar and non-polar parts of the chain. The beta sheets are shown in yellow in the second green scene. | ||
- <scene name='48/483890/2yly_alpha_helicies/1'>Alpha Helices</scene>, and <scene name='48/483890/2yly_beta_sheets/1'>Beta Sheets</scene> | - <scene name='48/483890/2yly_alpha_helicies/1'>Alpha Helices</scene>, and <scene name='48/483890/2yly_beta_sheets/1'>Beta Sheets</scene> | ||
