Sandbox WWC11: Difference between revisions
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'''Correlation to Cardiovascular Disease''' | '''Correlation to Cardiovascular Disease''' | ||
Although MPO plays a key role in the fight against unwanted intruders, it has also been shown to turn those destructive powers against the body. Elevated levels of MPO in the blood has been found in patients with cardiovascular disease. <ref name="CAD">PMID:11694155</ref> It is speculated that over activation of the immune response causes inflammation, or damage to the surrounding tissue which increases risk of cardiovascular disease. More specifically, when MPO generate the oxidative agents such as HOCl, it not only chloronate invaders, but can also chloronate lipoproteins (both LDL and HDL). This changes the lipoprotein's affinity for the cell wall which can lead to plaque buildup. It can also effects the endothelial cells lining the vein or artery. <ref name="Specifics on Correlation to CVD">PMID:16476484</ref> | |||
Another of the identified affects of MPO on endothelial cells is in the production of nitric oxide (NO). This is a vasodilator that is inhibited when oxidized by MPO. Myloperoxidase can also oxidize NO2 - to its radical form which has been identified as a major contributor to inflammation. <ref name="Specifics on Correlation to CVD">PMID:16476484</ref> Because of this clear correlation between MPO activity and the manifestation of cardiovascular disease, it has the potential to be used as an indicator of a cardiovascular problem. <ref name="Use in Medicine">PMID:12865732</ref> | |||
==3D structures of myeloperoxidase== | ==3D structures of myeloperoxidase== | ||
