Netrin: Difference between revisions

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'''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types.

== Function ==

'''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein.

~~== Disease ==~~

== Relevance ==

Netrin-1 is over-expressed in glioblastoma tumor<ref>PMID:23549787</ref>. Netrin-1 is a therapeutic target in cardiovascular diseases<ref>PMID:26209250</ref>.

== Structural highlights ==

The N-terminal of netrin-1 is homologous to the N-terminal domains of laminin (LN).

</StructureSection>

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 <StructureSection load='4ove' size='340' side='right' caption='Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code [[4ove]])' scene=''>
-'''Netrins''' (Net) direct cell and axon migration during development.  Netrins are chemotropic.  The growing axon moves either toward or away from netrin concentration.  Netrins influence the formation of a variety of tissues.  They act as chemoattractants for some cell types and chemorepellent for other types.
 == Function ==
+'''Netrins''' (Net) direct cell and axon migration during development.  Netrins are chemotropic.  The growing axon moves either toward or away from netrin concentration.  Netrins influence the formation of a variety of tissues.  They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>.  '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein.
-== Disease ==
 == Relevance ==
+Netrin-1 is over-expressed in glioblastoma tumor<ref>PMID:23549787</ref>.  Netrin-1 is a therapeutic target in cardiovascular diseases<ref>PMID:26209250</ref>.
 == Structural highlights ==
+The N-terminal of netrin-1 is homologous to the N-terminal domains of laminin (LN).
 </StructureSection>