Sandbox WWC7: Difference between revisions

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This image shows the general code by which PPR proteins recognize and bind RNA in a modular fashion<ref name = "barkan"/>
This image shows the general code by which PPR proteins recognize and bind RNA in a modular fashion<ref name = "barkan"/>


While crystallographic structures show PPR10 binding RNA in a dimerized configuration, further evidence by EC-SY-SAX [http://www.sciencedirect.com/science/article/pii/S0021967309003057] has shown that this result is likely an artifact of the high concentrations necessary for crystallography. In a natural setting, PPR10 does not form a dimer.<ref name = "gully">DOI:10.1093/nar/gkv027</ref><ref name = "li">DOI:10.1074/jbc.M114.575472</ref>
While crystallographic structures show PPR10 binding RNA in a dimerized configuration, further evidence by [EC-SY-SAX http://www.sciencedirect.com/science/article/pii/S0021967309003057] has shown that this result is likely an artifact of the high concentrations necessary for crystallography. In a natural setting, PPR10 does not form a dimer.<ref name = "gully">DOI:10.1093/nar/gkv027</ref><ref name = "li">DOI:10.1074/jbc.M114.575472</ref>


===RNA Stabilization===
===RNA Stabilization===