5d3w: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5d3w is ~~ON HOLD until Paper Publication~~

==Crystal Structure of the P-Rex1 PH domain with Sulfate Bound==

~~Authors~~: ~~Cash~~, J.N., ~~Tesmer~~, J.J.G.

== Structural highlights ==

<table><tr><td colspan='2'>[[5d3w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D3W OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D3W FirstGlance].

~~Description:~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5d27|5d27]], [[5d3v|5d3v]], [[5d3x|5d3x]]</td></tr>

[[Category: Cash, J.N]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d3w OCA], [http://pdbe.org/5d3w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d3w RCSB], [http://www.ebi.ac.uk/pdbsum/5d3w PDBsum]</td></tr>

[[Category: Tesmer, J.J.G]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN]] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

__TOC__

</StructureSection>

[[Category: Cash, J N]]

[[Category: Tesmer, J J.G]]

[[Category: Beta sandwich]]

[[Category: Lipid binding protein]]

[[Category: Phosphatidylinositol-binding]]

[[Category: Pleckstrin homology domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5d3w is ON HOLD  until Paper Publication
+==Crystal Structure of the P-Rex1 PH domain with Sulfate Bound==
+<StructureSection load='5d3w' size='340' side='right' caption='[[5d3w]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors: Cash, J.N., Tesmer, J.J.G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5d3w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D3W FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d27|5d27]], [[5d3v|5d3v]], [[5d3x|5d3x]]</td></tr>
-[[Category: Cash, J.N]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d3w OCA], [http://pdbe.org/5d3w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d3w RCSB], [http://www.ebi.ac.uk/pdbsum/5d3w PDBsum]</span></td></tr>
-[[Category: Tesmer, J.J.G]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN]] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
+__TOC__
+</StructureSection>
+[[Category: Cash, J N]]
+[[Category: Tesmer, J J.G]]
+[[Category: Beta sandwich]]
+[[Category: Lipid binding protein]]
+[[Category: Phosphatidylinositol-binding]]
+[[Category: Pleckstrin homology domain]]