5d27: Difference between revisions
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==Crystal Structure of the P-Rex1 PH domain== | |||
<StructureSection load='5d27' size='340' side='right' caption='[[5d27]], [[Resolution|resolution]] 1.92Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5d27]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D27 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d27 OCA], [http://pdbe.org/5d27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d27 RCSB], [http://www.ebi.ac.uk/pdbsum/5d27 PDBsum]</span></td></tr> | ||
[[Category: Cash, J | </table> | ||
[[Category: Tesmer, J | == Function == | ||
[[http://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN]] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cash, J N]] | |||
[[Category: Tesmer, J J.G]] | |||
[[Category: Beta sandwich]] | |||
[[Category: Lipid binding protein]] | |||
[[Category: Phosphatidylinositol-binding]] | |||
[[Category: Pleckstrin homology domain]] | |||
Revision as of 16:33, 10 May 2016
Crystal Structure of the P-Rex1 PH domain
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