5fi1: Difference between revisions
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==Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42== | |||
<StructureSection load='5fi1' size='340' side='right' caption='[[5fi1]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fi1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FI1 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d27|5d27]], [[5d3v|5d3v]], [[5d3w|5d3w]], [[5d3x|5d3x]], [[5d3y|5d3y]], [[5fi0|5fi0]]</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi1 OCA], [http://pdbe.org/5fi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fi1 RCSB], [http://www.ebi.ac.uk/pdbsum/5fi1 PDBsum]</span></td></tr> | ||
[[Category: Tesmer, J | </table> | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN]] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cash, J N]] | |||
[[Category: Tesmer, J J.G]] | |||
[[Category: Dbl homology domain]] | |||
[[Category: Gtpase]] | |||
[[Category: Pleckstrin homology domain]] | |||
[[Category: Protein binding]] | |||
[[Category: Rhogef]] | |||
[[Category: Signaling protein]] | |||
Revision as of 17:23, 10 May 2016
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42
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