4zm2: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 4zm2 is ON HOLD~~

==Antitoxin Phd from phage P1 in complex with its operator DNA inverted repeat in a monoclinic space group==

~~Authors: Garcia-Pino, A., Loris, R.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4zm2]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZM2 FirstGlance]. <br>

~~Description:~~ Antitoxin Phd from phage P1 in complex with its operator DNA inverted repeat in a monoclinic space group

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zm2 OCA], [http://pdbe.org/4zm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zm2 RCSB], [http://www.ebi.ac.uk/pdbsum/4zm2 PDBsum]</span></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PHD_BPP1 PHD_BPP1]] Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that binds to the doc toxin and neutralizes its toxic effect. Bacteriophage P1 lysogenizes bacteria as a low-copy number plasmid. Phd and doc proteins function in unison to stabilize plasmid number by inducing a lethal response to P1 plasmid prophage loss.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref> Binds to its own promoter repressing its expression; toxin doc acts as a corepressor or derepressor depending on the ratio, repressing or inducing expression.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Garcia-Pino, A]]

[[Category: Loris, R]]

[[Category: Conditional cooperativity]]

[[Category: Dna binding]]

[[Category: Intrinsic disorder]]

[[Category: Protein-dna complex]]

[[Category: Toxin-antitoxin]]

[[Category: Transcription]]

[[Category: Transcription factor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4zm2 is ON HOLD
+==Antitoxin Phd from phage P1 in complex with its operator DNA inverted repeat in a monoclinic space group==
+<StructureSection load='4zm2' size='340' side='right' caption='[[4zm2]], [[Resolution|resolution]] 3.88&Aring;' scene=''>
-Authors: Garcia-Pino, A., Loris, R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4zm2]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZM2 FirstGlance]. <br>
-Description: Antitoxin Phd from phage P1 in complex with its operator DNA inverted repeat in a monoclinic space group
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zm2 OCA], [http://pdbe.org/4zm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zm2 RCSB], [http://www.ebi.ac.uk/pdbsum/4zm2 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PHD_BPP1 PHD_BPP1]] Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that binds to the doc toxin and neutralizes its toxic effect. Bacteriophage P1 lysogenizes bacteria as a low-copy number plasmid. Phd and doc proteins function in unison to stabilize plasmid number by inducing a lethal response to P1 plasmid prophage loss.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref>   Binds to its own promoter repressing its expression; toxin doc acts as a corepressor or derepressor depending on the ratio, repressing or inducing expression.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Garcia-Pino, A]]
 [[Category: Loris, R]]
+[[Category: Conditional cooperativity]]
+[[Category: Dna binding]]
+[[Category: Intrinsic disorder]]
+[[Category: Protein-dna complex]]
+[[Category: Toxin-antitoxin]]
+[[Category: Transcription]]
+[[Category: Transcription factor]]