4yqf: Difference between revisions
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==GTPase domain of Human Septin 9== | |||
<StructureSection load='4yqf' size='340' side='right' caption='[[4yqf]], [[Resolution|resolution]] 2.73Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4yqf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YQF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqf OCA], [http://pdbe.org/4yqf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yqf RCSB], [http://www.ebi.ac.uk/pdbsum/4yqf PDBsum]</span></td></tr> | ||
[[ | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [[http://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN]] Neuralgic amyotrophy. A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1.<ref>PMID:10339604</ref> The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: Macedo, J | [[http://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. | ||
[[Category: Matos, S. | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Araujo, A P.U]] | |||
[[Category: Garratt, R C]] | |||
[[Category: Leonardo, D A]] | |||
[[Category: Macedo, J N]] | |||
[[Category: Matos, S O]] | |||
[[Category: Pereira, H M]] | |||
[[Category: Cytoskeleton component. septin gtpase]] | |||
[[Category: Hydrolase]] | |||
