4yof: Difference between revisions
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==DosS GAFA Domain Reduced Nitric Oxide Bound Crystal Structure== | |||
<StructureSection load='4yof' size='340' side='right' caption='[[4yof]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4yof]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YOF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ynr|4ynr]], [[2w3d|2w3d]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yof OCA], [http://pdbe.org/4yof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yof RCSB], [http://www.ebi.ac.uk/pdbsum/4yof PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/DEVS_MYCTO DEVS_MYCTO]] Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaerobic growth) Fe(2+) form is probably active for phosphate transfer. It is probably reduced by flavin nucleotides such as FMN and FAD. May be the primary sensor for CO. Donates a phosphate group to DevR (DosR) (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Histidine kinase]] | |||
[[Category: Madrona, Y]] | [[Category: Madrona, Y]] | ||
[[Category: Doss]] | |||
[[Category: Gas sensor]] | |||
[[Category: Heme]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Tuberculosis]] | |||
Revision as of 12:56, 11 May 2016
DosS GAFA Domain Reduced Nitric Oxide Bound Crystal Structure
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