4ys1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 4ys1 is ON HOLD until Mar 16 2017~~

==Human Aldose Reductase complexed with a ligand with an IDD structure (2) at 1.07 A.==

~~Authors: Rechlin, C., Heine, A., Klebe, G.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4ys1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YS1 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YS1 FirstGlance].

~~Description:~~ Human Aldose Reductase complexed with a ligand with an IDD structure (2) at 1.07 A.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=4G7:3-({[2-(CARBOXYMETHOXY)-4-FLUOROBENZOYL]AMINO}METHYL)BENZOIC+ACID'>4G7</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ys1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ys1 OCA], [http://pdbe.org/4ys1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ys1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ys1 PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

__TOC__

</StructureSection>

[[Category: Aldehyde reductase]]

[[Category: Heine, A]]

[[Category: Klebe, G]]

[[Category: Rechlin, C]]

[[Category: ~~Klebe, G~~]]

[[Category: Complex]]

[[Category: Inhibitor]]

[[Category: Oxidoreductase]]

[[Category: Tim barrel]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4ys1 is ON HOLD  until Mar 16 2017
+==Human Aldose Reductase complexed with a ligand with an IDD structure (2) at 1.07 A.==
+<StructureSection load='4ys1' size='340' side='right' caption='[[4ys1]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
-Authors: Rechlin, C., Heine, A., Klebe, G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ys1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YS1 FirstGlance]. <br>
-Description: Human Aldose Reductase complexed with a ligand with an IDD structure (2) at 1.07 A.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4G7:3-({[2-(CARBOXYMETHOXY)-4-FLUOROBENZOYL]AMINO}METHYL)BENZOIC+ACID'>4G7</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1us0|1us0]], [[4puu|4puu]], [[4puw|4puw]], [[4q7b|4q7b]], [[4qbx|4qbx]], [[4qr6|4qr6]], [[4rpq|4rpq]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ys1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ys1 OCA], [http://pdbe.org/4ys1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ys1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ys1 PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
+__TOC__
+</StructureSection>
+[[Category: Aldehyde reductase]]
 [[Category: Heine, A]]
+[[Category: Klebe, G]]
 [[Category: Rechlin, C]]
-[[Category: Klebe, G]]
+[[Category: Complex]]
+[[Category: Inhibitor]]
+[[Category: Oxidoreductase]]
+[[Category: Tim barrel]]