Sandbox WWC1: Difference between revisions
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clostridial neurotoxins. Curr. Top. Microbiol. | clostridial neurotoxins. Curr. Top. Microbiol. | ||
Immunol. 195:161–94 </ref> <ref> Oguma K, Fujinaga Y, Inoue K. 1995.Structure and function of Clostridium botulinum toxins. Microbiol. Immunol. 39:161–68 </ref> <ref> Lacy BD, Stevens RC. 1999. Sequence homology and structural analysis of the clostridial neurotoxins. J. Mol. Biol. 291: 1091–104 </ref> <ref> Popoff MR, Marvaud J-C. 1999. Structural and genomic features of clostridial neurotoxins. See Ref. 132, pp. 174– | Immunol. 195:161–94 </ref> <ref> Oguma K, Fujinaga Y, Inoue K. 1995.Structure and function of Clostridium botulinum toxins. Microbiol. Immunol. 39:161–68 </ref> <ref> Lacy BD, Stevens RC. 1999. Sequence homology and structural analysis of the clostridial neurotoxins. J. Mol. Biol. 291: 1091–104 </ref> <ref> Popoff MR, Marvaud J-C. 1999. Structural and genomic features of clostridial neurotoxins. See Ref. 132, pp. 174– | ||
201 </ref>). | 201 </ref>). | ||
The light chain contains the consensus sequence HELIH that codes for the binding of zinc, which subsequently regulates the endopeptidase activity of the light chain. | The light chain contains the <scene name='69/696299/Consensus_sequence_heilh/1'>consensus sequence HELIH</scene> that codes for the binding of zinc, which subsequently regulates the endopeptidase activity of the light chain. | ||
BTX also has two auxiliary proteins that compromise a multimeric complex: hemagglutinins (HA) and nonhemagglutinin (NTNH). HA and NTNH do not directly play a role in the toxic effect of BTX, but have an indirect role during ingestion of the protein by making the BTX more resistant to low pH environments and proteolytic enzymes found in the gut. | BTX also has two auxiliary proteins that compromise a multimeric complex: hemagglutinins (HA) and nonhemagglutinin (NTNH). HA and NTNH do not directly play a role in the toxic effect of BTX, but have an indirect role during ingestion of the protein by making the BTX more resistant to low pH environments and proteolytic enzymes found in the gut. | ||
