5a4o: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5a4o is ~~ON HOLD until Paper~~ Publication

==Crystal structure of BPSL1147, a PC4 homolog from Burkholderia pseudomallei K96243 (orthorhombic crystal form)==

== Structural highlights ==

<table><tr><td colspan='2'>[[5a4o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4O FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a4n|5a4n]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4o OCA], [http://pdbe.org/5a4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4o RCSB], [http://www.ebi.ac.uk/pdbsum/5a4o PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Homologs of the eukaryotic transcription coactivator PC4, which also functions in DNA repair and oxidative stress, were recently identified in prokaryotes. Crystallographic analysis of BPSL1147, a putative homolog from the pathogen Burkholderia pseudomallei K96243, reveals a highly conserved core structure and suggests a nucleic acid binding mode similar to that of PC4. Knock-out and complementation experiments do not reveal distinguishing phenotypes under normal growth conditions or in the presence of H2O2, arguing against a critical role in repair or the oxidative stress response of Burkholderia. These results may reflect redundancy or point at a bacteriophage origin of Burkholderia PC4 homologs.

~~Authors:~~ Werten, S., Bayer, N., Hinrichs, W.

Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4.,Werten S, Kohler C, Bayer NJ, Steinmetz I, Hinrichs W Gene. 2016 Feb 15;577(2):140-7. doi: 10.1016/j.gene.2015.11.037. Epub 2015 Nov, 25. PMID:26625975<ref>PMID:26625975</ref>

~~Description: Crystal structure of BPSL1147~~, a ~~PC4 homolog from Burkholderia pseudomallei K96243 (orthorhombic crystal form)~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased Structures~~]]

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Bayer, N]]

[[Category: Hinrichs, W]]

[[Category: Werten, S]]

[[Category: ~~Bayer, N~~]]

[[Category: Dna replication]]

[[Category: Dna-binding protein]]

[[Category: Recombination and repair]]

[[Category: Ssdna-binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5a4o is ON HOLD  until Paper Publication
+==Crystal structure of BPSL1147, a PC4 homolog from Burkholderia pseudomallei K96243 (orthorhombic crystal form)==
+<StructureSection load='5a4o' size='340' side='right' caption='[[5a4o]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5a4o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4O FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a4n|5a4n]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4o OCA], [http://pdbe.org/5a4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4o RCSB], [http://www.ebi.ac.uk/pdbsum/5a4o PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Homologs of the eukaryotic transcription coactivator PC4, which also functions in DNA repair and oxidative stress, were recently identified in prokaryotes. Crystallographic analysis of BPSL1147, a putative homolog from the pathogen Burkholderia pseudomallei K96243, reveals a highly conserved core structure and suggests a nucleic acid binding mode similar to that of PC4. Knock-out and complementation experiments do not reveal distinguishing phenotypes under normal growth conditions or in the presence of H2O2, arguing against a critical role in repair or the oxidative stress response of Burkholderia. These results may reflect redundancy or point at a bacteriophage origin of Burkholderia PC4 homologs.
-Authors: Werten, S., Bayer, N., Hinrichs, W.
+Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4.,Werten S, Kohler C, Bayer NJ, Steinmetz I, Hinrichs W Gene. 2016 Feb 15;577(2):140-7. doi: 10.1016/j.gene.2015.11.037. Epub 2015 Nov, 25. PMID:26625975<ref>PMID:26625975</ref>
-Description: Crystal structure of BPSL1147, a PC4 homolog from Burkholderia pseudomallei K96243 (orthorhombic crystal form)
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 5a4o" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bayer, N]]
 [[Category: Hinrichs, W]]
 [[Category: Werten, S]]
-[[Category: Bayer, N]]
+[[Category: Dna replication]]
+[[Category: Dna-binding protein]]
+[[Category: Recombination and repair]]
+[[Category: Ssdna-binding protein]]