5fzk

Crystal structure of the catalytic domain of human JARID1B in complex with 3D fragment N,3-dimethyl-N-(pyridin-3-ylmethyl)-1,2-oxazole-5- carboxamide (N10051a) (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)

spinqualitylabelsall models 5fzk, resolution 2.05Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5fzk is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, DMS, EDO, MN, NRW, PO4, ZN Related: 5fyc, 5fyh, 5fyi, 5fym, 5fys, 5fyt, 5fyu, 5fyv, 5fyy, 5fyz, 5fz0, 5fz1, 5fz3, 5fz4, 5fz6, 5fz7, 5fz8, 5fz9, 5fza, 5fzb, 5fzc, 5fzd, 5fze, 5fzf, 5fzg, 5fzh, 5fzi, 5fzl, 5fzm, 5fzo Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.

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