4uht: Difference between revisions
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==Crystal structure of the DNA binding domain of CpxR from E. coli== | |||
<StructureSection load='4uht' size='340' side='right' caption='[[4uht]], [[Resolution|resolution]] 1.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4uht]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhj|4uhj]], [[4uhk|4uhk]], [[4uhs|4uhs]]</td></tr> | |||
[[Category: Alzari, P | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uht OCA], [http://pdbe.org/4uht PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uht RCSB], [http://www.ebi.ac.uk/pdbsum/4uht PDBsum]</span></td></tr> | ||
[[Category: Mechaly, A | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CPXR_ECOLI CPXR_ECOLI]] Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed:7883164, PubMed:9401031). Binds and activates transcription from the degP promoter (PubMed:7883164); binding is enhanced by phosphorylation (PubMed:9401031). This system combats a variety of extracytoplasmic protein-mediated toxicities by increasing the transcription of the periplasmic protease, DegP in concert with sigma factor E (PubMed:7883164), as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed:23416055).<ref>PMID:23416055</ref> <ref>PMID:7883164</ref> <ref>PMID:9401031</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Alzari, P M.A]] | |||
[[Category: Mechaly, A E]] | |||
[[Category: Transcription]] | |||
Revision as of 11:16, 12 May 2016
Crystal structure of the DNA binding domain of CpxR from E. coli
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