4z2z: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4z2z is ~~ON HOLD until Paper Publication~~

==New crystal structure of yeast Ddi1 aspartyl protease reveals substrate engagement mode==

~~Authors~~: ~~Trempe, J~~.-F., ~~Feng~~, X., ~~Gehring~~, K.

== Structural highlights ==

<table><tr><td colspan='2'>[[4z2z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2Z FirstGlance]. <br>

~~Description~~: ~~New crystal structure~~ of ~~yeast Ddi1 aspartyl protease reveals substrate engagement mode~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2z OCA], [http://pdbe.org/4z2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2z RCSB], [http://www.ebi.ac.uk/pdbsum/4z2z PDBsum]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DDI1_YEAST DDI1_YEAST]] Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.<ref>PMID:10330187</ref> <ref>PMID:11238935</ref> <ref>PMID:12051757</ref> <ref>PMID:12925750</ref> <ref>PMID:15964793</ref> <ref>PMID:17144915</ref> <ref>PMID:16478980</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Feng, X]]

[[Category: Gehring, K]]

[[Category: Trempe, J.-F]]

[[Category: Trempe, J F]]

[[Category: ~~Feng, X~~]]

[[Category: Ddi1]]

[[Category: Hydrolase]]

[[Category: Protease]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4z2z is ON HOLD  until Paper Publication
+==New crystal structure of yeast Ddi1 aspartyl protease reveals substrate engagement mode==
+<StructureSection load='4z2z' size='340' side='right' caption='[[4z2z]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Trempe, J.-F., Feng, X., Gehring, K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4z2z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2Z FirstGlance]. <br>
-Description: New crystal structure of yeast Ddi1 aspartyl protease reveals substrate engagement mode
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2z OCA], [http://pdbe.org/4z2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2z RCSB], [http://www.ebi.ac.uk/pdbsum/4z2z PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DDI1_YEAST DDI1_YEAST]] Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.<ref>PMID:10330187</ref> <ref>PMID:11238935</ref> <ref>PMID:12051757</ref> <ref>PMID:12925750</ref> <ref>PMID:15964793</ref> <ref>PMID:17144915</ref> <ref>PMID:16478980</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Feng, X]]
 [[Category: Gehring, K]]
-[[Category: Trempe, J.-F]]
+[[Category: Trempe, J F]]
-[[Category: Feng, X]]
+[[Category: Ddi1]]
+[[Category: Hydrolase]]
+[[Category: Protease]]