4z7m: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4z7m ~~is ON HOLD until Paper Publication~~

==Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity==

~~Authors~~: ~~Rose, J~~.A.~~, Lahiri, S~~.D., ~~McKinney~~, ~~D.C.~~, ~~Albert~~, R., ~~Morningstar~~, M., ~~Shapiro~~, A.B., ~~Fisher~~, S.F., ~~Fleming, P~~.R.

== Structural highlights ==

<table><tr><td colspan='2'>[[4z7m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z7M OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z7M FirstGlance].

~~Description~~: ~~Novel Inhibitors~~ of ~~Bacterial Methionine Aminopeptidase with Broad~~-~~Spectrum Biochemical Activity~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=4L9:N~2~-[(3,5-DIFLUOROPHENYL)ACETYL]-N-[(3S,7R)-1-METHYL-2-OXO-7-PHENYL-2,3,4,7-TETRAHYDRO-1H-AZEPIN-3-YL]-L-ALANINAMIDE'>4L9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </td></tr>

[[Category: ~~Mckinney~~, ~~D.C~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z7m OCA], [http://pdbe.org/4z7m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z7m RCSB], [http://www.ebi.ac.uk/pdbsum/4z7m PDBsum]</td></tr>

[[Category: Fleming, P.R]]

</table>

[[Category: Lahiri, S.D]]

== Function ==

[[Category: ~~Fisher~~, ~~S.F~~]]

[[http://www.uniprot.org/uniprot/MAP1_ECO57 MAP1_ECO57]] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

__TOC__

</StructureSection>

[[Category: Methionyl aminopeptidase]]

[[Category: Albert, R]]

[[Category: Fisher, S F]]

[[Category: Fleming, P R]]

[[Category: Lahiri, S D]]

[[Category: McKinney, D C]]

[[Category: Morningstar, M]]

[[Category: Rose, J.A]]

[[Category: Rose, J A]]

[[Category: ~~Albert~~, R]]

[[Category: Shapiro, A B]]

[[Category: ~~Shapiro, A.B~~]]

[[Category: Antibacterial]]

[[Category: Azepinone]]

[[Category: Drug discovery]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Methionine aminopeptidase]]

[[Category: Structure-based design]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4z7m is ON HOLD  until Paper Publication
+==Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity==
+<StructureSection load='4z7m' size='340' side='right' caption='[[4z7m]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
-Authors: Rose, J.A., Lahiri, S.D., McKinney, D.C., Albert, R., Morningstar, M., Shapiro, A.B., Fisher, S.F., Fleming, P.R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4z7m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z7M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z7M FirstGlance]. <br>
-Description: Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4L9:N~2~-[(3,5-DIFLUOROPHENYL)ACETYL]-N-[(3S,7R)-1-METHYL-2-OXO-7-PHENYL-2,3,4,7-TETRAHYDRO-1H-AZEPIN-3-YL]-L-ALANINAMIDE'>4L9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>
-[[Category: Mckinney, D.C]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z7m OCA], [http://pdbe.org/4z7m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z7m RCSB], [http://www.ebi.ac.uk/pdbsum/4z7m PDBsum]</span></td></tr>
-[[Category: Fleming, P.R]]
+</table>
-[[Category: Lahiri, S.D]]
+== Function ==
-[[Category: Fisher, S.F]]
+[[http://www.uniprot.org/uniprot/MAP1_ECO57 MAP1_ECO57]] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
+__TOC__
+</StructureSection>
+[[Category: Methionyl aminopeptidase]]
+[[Category: Albert, R]]
+[[Category: Fisher, S F]]
+[[Category: Fleming, P R]]
+[[Category: Lahiri, S D]]
+[[Category: McKinney, D C]]
 [[Category: Morningstar, M]]
-[[Category: Rose, J.A]]
+[[Category: Rose, J A]]
-[[Category: Albert, R]]
+[[Category: Shapiro, A B]]
-[[Category: Shapiro, A.B]]
+[[Category: Antibacterial]]
+[[Category: Azepinone]]
+[[Category: Drug discovery]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Methionine aminopeptidase]]
+[[Category: Structure-based design]]