5c3f: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5c3f ~~is ON HOLD until Paper Publication~~

==Crystal structure of Mcl-1 bound to BID-MM==

~~Authors~~: ~~Miles, J~~.A.~~, Yeo, D~~.J.~~, Rowell, P~~.~~, Rodriguez~~-~~Marin~~, S.~~, Pask, C~~.M., ~~Warriner, S~~.L., ~~Edwards~~, T.A., ~~Wilson, A~~.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5c3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3F OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C3F FirstGlance].

~~Description: Crystal structure of Mcl-1 bound to BID-MM~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>

~~[[Category: Warriner~~, S.~~L]]~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3f OCA], [http://pdbe.org/5c3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c3f RCSB], [http://www.ebi.ac.uk/pdbsum/5c3f PDBsum]</td></tr>

[[Category: Edwards, T.A]]

</table>

[[Category: ~~Wilson~~, A.J]]

== Function ==

[[Category: Pask, C.M]]

[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Edwards, T A]]

[[Category: Miles, J A]]

[[Category: Pask, C M]]

[[Category: Rodriguez-Marin, S]]

~~[[Category: Yeo, D.J]]~~

~~[[Category: Miles, J.A]]~~

[[Category: Rowell, P]]

[[Category: Warriner, S L]]

[[Category: Wilson, A J]]

[[Category: Yeo, D J]]

[[Category: Apoptosis]]

[[Category: Bcl-2 family]]

[[Category: Bh3]]

[[Category: Complex]]

[[Category: Stapled peptide]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5c3f is ON HOLD  until Paper Publication
+==Crystal structure of Mcl-1 bound to BID-MM==
+<StructureSection load='5c3f' size='340' side='right' caption='[[5c3f]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
-Authors: Miles, J.A., Yeo, D.J., Rowell, P., Rodriguez-Marin, S., Pask, C.M., Warriner, S.L., Edwards, T.A., Wilson, A.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5c3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C3F FirstGlance]. <br>
-Description: Crystal structure of Mcl-1 bound to BID-MM
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
-[[Category: Warriner, S.L]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3f OCA], [http://pdbe.org/5c3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c3f RCSB], [http://www.ebi.ac.uk/pdbsum/5c3f PDBsum]</span></td></tr>
-[[Category: Edwards, T.A]]
+</table>
-[[Category: Wilson, A.J]]
+== Function ==
-[[Category: Pask, C.M]]
+[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Edwards, T A]]
+[[Category: Miles, J A]]
+[[Category: Pask, C M]]
 [[Category: Rodriguez-Marin, S]]
-[[Category: Yeo, D.J]]
-[[Category: Miles, J.A]]
 [[Category: Rowell, P]]
+[[Category: Warriner, S L]]
+[[Category: Wilson, A J]]
+[[Category: Yeo, D J]]
+[[Category: Apoptosis]]
+[[Category: Bcl-2 family]]
+[[Category: Bh3]]
+[[Category: Complex]]
+[[Category: Stapled peptide]]