Sandbox WWC6: Difference between revisions
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Studies suggest that pore formation is achieved through a nonlytic intermediate oligomer, known as a prepore. The prepore model proposal suggests that the monomeric components assemble on the cell membrane surfacte into a prepore with prestem subunits packed inside. The formed prepore then goes through a conformational change prestem, forming the β-barrel pore. Several issues with the proposed pore formation mechanism have been identified including steric hindrance of the packed prestem structure. | Studies suggest that pore formation is achieved through a nonlytic intermediate oligomer, known as a prepore. The prepore model proposal suggests that the monomeric components assemble on the cell membrane surfacte into a prepore with prestem subunits packed inside. The formed prepore then goes through a conformational change prestem, forming the β-barrel pore. Several issues with the proposed pore formation mechanism have been identified including steric hindrance of the packed prestem structure. | ||
This image shows the | [[Image:Ncomms5897-f5.jpg]] | ||
This image shows the proposed mechanism of pore formation in the cell membrane. <ref>http://www.nature.com/ncomms/2014/140929/ncomms5897/full/ncomms5897.html<ref> | |||
===Role in infection=== | ===Role in infection=== | ||
