4zeg: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4zeg is ~~ON HOLD until Apr 20 2017~~

==Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor==

~~Authors~~: ~~Qiu~~, W., ~~Plotnikova~~, O., ~~Feher~~, M., ~~Awrey~~, D.E., ~~Battaile, K~~., ~~Chirgadze~~, N.Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[4zeg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEG OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEG FirstGlance].

~~Description~~: ~~Crystal structure of TTK~~ kinase ~~domain in complex with a pyrazolopyrimidine inhibitor~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=052:N-CYCLOPROPYL-2-METHYL-4-(7-{[2-(MORPHOLIN-4-YL)ETHYL]AMINO}-5-PHENOXYPYRAZOLO[1,5-A]PYRIMIDIN-3-YL)BENZAMIDE'>052</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeg OCA], [http://pdbe.org/4zeg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zeg RCSB], [http://www.ebi.ac.uk/pdbsum/4zeg PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Dual-specificity kinase]]

[[Category: Awrey, D E]]

[[Category: Battaile, K]]

[[Category: Chirgadze, N Y]]

[[Category: Feher, M]]

[[Category: ~~Chirgadze~~, ~~N.Y]]~~

[[Category: Plotnikova, O]]

~~[[Category: Awrey, D.E~~]]

[[Category: Qiu, W]]

[[Category: ~~Plotnikova, O~~]]

[[Category: Inhibitor]]

[[Category: Kinase]]

[[Category: Transferase-transferase inhibitor complex]]

[[Category: Ttk]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4zeg is ON HOLD  until Apr 20 2017
+==Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor==
+<StructureSection load='4zeg' size='340' side='right' caption='[[4zeg]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
-Authors: Qiu, W., Plotnikova, O., Feher, M., Awrey, D.E., Battaile, K., Chirgadze, N.Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4zeg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEG FirstGlance]. <br>
-Description: Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=052:N-CYCLOPROPYL-2-METHYL-4-(7-{[2-(MORPHOLIN-4-YL)ETHYL]AMINO}-5-PHENOXYPYRAZOLO[1,5-A]PYRIMIDIN-3-YL)BENZAMIDE'>052</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeg OCA], [http://pdbe.org/4zeg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zeg RCSB], [http://www.ebi.ac.uk/pdbsum/4zeg PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Dual-specificity kinase]]
+[[Category: Awrey, D E]]
 [[Category: Battaile, K]]
+[[Category: Chirgadze, N Y]]
 [[Category: Feher, M]]
-[[Category: Chirgadze, N.Y]]
+[[Category: Plotnikova, O]]
-[[Category: Awrey, D.E]]
 [[Category: Qiu, W]]
-[[Category: Plotnikova, O]]
+[[Category: Inhibitor]]
+[[Category: Kinase]]
+[[Category: Transferase-transferase inhibitor complex]]
+[[Category: Ttk]]