Sandbox WWC2: Difference between revisions
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As previously stated, the function of MAO-A is to deaminate 5-hydroxytryptamine (5-HT), epinephrine, norepinephrine, dopamine, tyramine, and N,N-dimethyltryptamine (DMT). When neurons release neurotransmitters into the synaptic cleft to bind to a receptor, some of the neurotransmitters do not bind to the receptor and are not reabsorbed. The monoamine oxidase enzymes are responsible for oxidizing some of these "free" neurotransmitters in an attempt to prevent their binding to unintended receptors, potentially causing deleterious side effects; they are also responsible for maintaining a steady state of certain neurotransmitters. | As previously stated, the function of MAO-A is to deaminate 5-hydroxytryptamine (5-HT), epinephrine, norepinephrine, dopamine, tyramine, and N,N-dimethyltryptamine (DMT). When neurons release neurotransmitters into the synaptic cleft to bind to a receptor, some of the neurotransmitters do not bind to the receptor and are not reabsorbed. The monoamine oxidase enzymes are responsible for oxidizing some of these "free" neurotransmitters in an attempt to prevent their binding to unintended receptors, potentially causing deleterious side effects; they are also responsible for maintaining a steady state of certain neurotransmitters. | ||
Although MAO-A is found concentrated in catecholaminergic neurons, it is primarily found in the digestive system, while MAO-B is found more abundantly in the brain. | Although MAO-A is found concentrated in catecholaminergic neurons, it is primarily found in the digestive system, while MAO-B is found more abundantly in the brain. | ||
There are two prevalent polymorphisms of the human MAOA gene, these include the low activity form (MAOA-L), which produces a smaller amount of the enzyme, and high activity form (MAOA-H), which results in the production of high levels of MAO-A [https://news.brown.edu/articles/2009/01/hotsauce]. Recent studies have found that individuals with the MAOA-L gene tend to display slightly higher levels of aggression than individuals with the MAOA-H gene (especially in the case of high-provocation situations). | There are two prevalent polymorphisms of the human MAOA gene, these include the low activity form (MAOA-L), which produces a smaller amount of the enzyme, and high activity form (MAOA-H), which results in the production of high levels of MAO-A [https://news.brown.edu/articles/2009/01/hotsauce]. Recent studies have found that individuals with the MAOA-L gene tend to display slightly higher levels of aggression than individuals with the MAOA-H gene (especially in the case of high-provocation situations). [http://scholar.harvard.edu/files/dtingley/files/pnas-2009.pdf] | ||
Due to this association between aggression and MAO-A polymorphisms, the human MAOA gene has been dubbed the "warrior gene". | |||
== Disease == | == Disease == | ||
